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Background: Effective biomarkers are urgently needed in the clinical settings. However, most biomarkers are currently developed from single type of omics data. The goal of this study is to identify prognostic prostate cancer signatures using transcriptomics and metabolomics profiles jointly aiming to capture wider spectrum of biological information.

Methods: In this study, we included 94 tumor and 48 adjacency normal samples with both transcriptomics and metabolomics profiles from Dana-Farber/Harvard Cancer Center SPORE Prostate Cancer Cohort. There were 85 patients being followed up with median length of 2.02 years including 3 lethal and 8 progression cases. We first constructed a multi-omics covering network that contained minimal set of variable pairs but sufficiently rich to account for observed inter-patient variations. The network was built on known gene-metabolite interaction pairs from Pathway …