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Popularity of herbal remedies is increasing day by day despite the presence of synthetic drugs to treat the Liver Diseases owing to the adverse effects and high cost of synthetic drugs. Silymarin has tremendous potential for the treatment of various liver disorders because of its high antioxidant potential as liver diseases are associated with increased oxidative stress. The low oral bioavailability of Silymarin continues to be a major challenge in the development of its formulations having clinical efficacy. Our idea was to constitute a pharmaceutical composition of Silymarin with natural products as bioenhancers that might work positively and synergistically in the control of hepatotoxicity.

In this work, various combinations of Silymarin with natural bioenhancers such as Lysergol (L), Piperine (P) and Fulvic acid (FA) were prepared and their …