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The substantial T lymphocyte infiltrate found in cases of nasopharyngeal carcinoma (NPC) has been implicated in the promotion of both tumor growth and immune escape. Conversely, because malignant NPC cells harbor the Epstein-Barr virus, this tumor is a candidate for virus-specific T cell-based therapies. Preventing the accumulation of tumor-promoting T cells or enhancing the recruitment of tumor-specific cytotoxic T cells offers therapeutic potential. However, the mechanisms involved in T cell recruitment to this tumor are poorly understood. Comparing memory T cell subsets that have naturally infiltrated NPC tissue with their counterparts from matched blood revealed enrichment of CD8⁺, CD4⁺, and regulatory T cells expressing the chemokine receptor CXCR6 in tumor tissue. CD8⁺ and (nonregulatory) CD4⁺ T cells also were more frequently CCR5⁺ in tumor than in blood. Ex vivo studies demonstrated that …