作者
Miranda EMC Christianen, Irma M Verdonck-de Leeuw, Patricia Doornaert, Olga Chouvalova, Roel JHM Steenbakkers, Phil W Koken, C René Leemans, Sjoukje F Oosting, Jan LN Roodenburg, Bernard FAM van der Laan, Ben J Slotman, Hendrik P Bijl, Johannes A Langendijk
发表日期
2015/10/1
期刊
Radiotherapy and Oncology
卷号
117
期号
1
页码范围
139-144
出版商
Elsevier
简介
Objectives
To identify patterns of long-term, radiation-induced swallowing dysfunction after definitive radiotherapy with or without chemotherapy (RT or CHRT) and to determine which factors may explain these patterns over time.
Material and methods
The study population consisted of 238 consecutive head and neck cancer patients treated with RT or CHRT. The primary endpoint was ⩾grade 2 swallowing dysfunction at 6, 12, 18 and 24 months after treatment. Cluster analysis was used to identify different patterns over time. The differences between the mean dose to the swallowing organs at risk for each pattern were determined by using dose maps.
Results
The cluster analysis revealed five patterns of swallowing dysfunction: low persistent, intermediate persistent, severe persistent, transient and progressive. Patients with high dose to the upper pharyngeal, laryngeal and lower pharyngeal region had the highest risk …
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MEMC Christianen, IM Verdonck-de Leeuw… - Radiotherapy and Oncology, 2015