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This study used the “functional muscle–bone unit” concept to investigate muscle–bone interaction of the lumbar spine in subjects of varying bone mineral density. It was found that unit bone mass corresponded to a relatively more muscle mass in subjects with reduced bone mineral density, indicating a relatively higher mechanical load from muscles exerted on trabecular bone.

Bone is an architecturally adaptive tissue which responds to mechanical loading. This study is proposed to use “functional muscle–bone unit” to reflect this muscle–bone interaction at spine in subjects with different bone mineral density.

The study was carried out in young normal subjects (21 females; age, 29 ± 3) and elderly subjects (155 females; age, 73 ± 3.9) with varying bone mineral density. Cross-sectional …