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This paper proposes a new virus spreading model, susceptible–infected–susceptible–recovered–susceptible, which is based on partial immunization and immune invalidity in a complex network. On the basis of mean-field theory, the epidemic dynamics behavior of this model in a uniform network and a scale-free network is studied. After modifying the formula for the effective spread rate, we obtain the theoretical result that the coexistence of partial immunization and immune failure does not affect the network spread threshold. At the same time, the experimental results show that the existence of the above two conditions greatly increases the spread of the virus and extends the diffusion range. The study also found that in the scale-free network, peak viral infection occurs at the beginning of the spreading process, and after the immunization strategy is applied, the early infection peak is effectively curbed.