查看文章

Gene fusions are widely observed in the RNA-seq data, many of which are formed by cancer susceptibility genes. The fusion gene is formed by chromosomal mutations and is an important factor in causing cancer. Studies have shown that only a small number of identified fusion genes play a role in the carcinogenesis process. Identifying those genes is important for the study and treatment of cancer. There are only few methods for measuring importance of cancer fusion genes due to the research level remaining in start stage. It is known that the importance of fusion gene can be obtained through the gene network. In this paper, the importance of cancer fusion gene based on synchronization stability theory is proposed. The algorithm evaluates the importance of nodes in the gene network based on the theory of “destructive equal importance”, and evaluates the importance of the corresponding fusion genes through …