作者
Yu Geng, Zhongmeng Zhao, Zhaofang Du, Yixuan Wang, Tian Zheng, Siyu He, Xuanping Zhang, Jiayin Wang
发表日期
2017/11/13
研讨会论文
2017 IEEE International Conference on Bioinformatics and Biomedicine (BIBM)
页码范围
1626-1633
出版商
IEEE
简介
The third generation sequencing data exposes great advantage on read length, which extremely benefits the genomic analyses. However, the third generation sequencing data implies error models different from the ones that the second generation data brings. It is suggested to correct sequencing errors, which could significantly reduce false positives in downstream analyses. Existing error correction approaches often suffer accuracy loss when the hybrid reads present diversity or the coverage varies. In this paper, we propose a novel method based on crowdsourcing strategy, which is implemented as CLTC. CLTC is also a hybrid correction algorithm, which consists of four steps. The second generation reads are first collected and mapped to the third generation reads. Then, the base difficult level is defined to describe the diversities on a base among a group of 2nd-generation reads covered it. The capability is …
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Y Geng, Z Zhao, Z Du, Y Wang, T Zheng, S He… - 2017 IEEE International Conference on Bioinformatics …, 2017