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The upsurge in commitment to safety from industry leaders and the implementation of better equipment and training have generated a 67% decline in recordable incident rates during the past two decades. Fatalities, however, have plateaued for the last decade and, in the past three years, have even increased. Current research indicates that human factors like fatigue play a major role in accident causation and fatality occurrence. To manage fatigue, it is essential to determine how fatigue can be objectively measured and predicted. The current body of knowledge suggests several potential predictors based upon laboratory experiments; however, no causal factors of fatigue have been validated in the context of construction work. The present study tested the hypothesis that a set of objective variables can predict variability in construction worker fatigue.