作者
Gian Luca Erre, Panagiotis Paliogiannis, Floriana Castagna, Arduino Aleksander Mangoni, Ciriaco Carru, Giuseppe Passiu, Angelo Zinellu
发表日期
2019/1
来源
European journal of clinical investigation
卷号
49
期号
1
页码范围
e13037
简介
Background
We conducted a meta‐analysis to review the available evidence regarding the associations between peripheral blood neutrophil‐to‐lymphocyte ratio (NLR) and platelet‐to‐lymphocyte ratio (PLR) and the presence of rheumatoid arthritis (RA).
Methods
PubMed, Web of Science and Scopus, from inception to January 2018, were searched for studies reporting on NLR and PLR in RA in comparison with healthy subjects. Standardized mean difference (SMD) was calculated with a confidence interval (CI) of 95%.
Results
Thirteen NLR studies (1550 RA patients and 1128 healthy controls) and 8 PLR studies (380 RA patients and 305 healthy controls) were included in the meta‐analysis. NLR and PLR were significantly higher in patients with RA when compared to controls (SMD = 0.79, 95% CI 0.55‐1.03; P < 0.001 and SMD = 0.66, 95% CI 0.43‐0.88; P < 0.001, respectively).
Conclusions
The NLR and …
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GL Erre, P Paliogiannis, F Castagna, AA Mangoni… - European journal of clinical investigation, 2019