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This work describes a method to quantify stenosis in X-ray coronary angiography. Vascular edge extraction is first performed based on a deformable spline algorithm. It makes use of directional S-Gabor filters to build an external energy field that is then used in a snake optimisation scheme. A string matching technique is then applied to match the contour points and obtain a trace between the matched points. This trace allows then computing the vessel diameter and deriving quantitative stenosis measurements. Experimental results are presented on simulated data and real images.