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Acorus calamus is a useful medicinal plant which gave benefit in different fields of medicines. This review deals with the different pharmacological activity of plant with different extract or solvents. This herb stimulates the power of intelligence and self expression in humans. This herb is generally used from the Ancient and Vedic periods due to its wonderful power of rejuvenation of brain, nervous system and normalizing the appetite. Acorus calamus is widely used in the pharmaceutical as well as on biotechnological scale because it has great potency and defense system. Acorus calamus has many wide varieties which were used in different studies possesses anti-inflammatory, anti-spasmodic, anti-protective and anti-hepatotoxic activities. Article also deals with various marketed product of Acorus calamus.