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The aim of this review is to study various parameters to improve the solubility and bioavilability of poorly water soluble drugs. The oral route of administration is the most preferred and widely acceptable route of delivery due to ease of ingestion for many drugs. Drugs with slow dissolution rate show the incomplete absorption leading to low bioavilability when orally administered. Various approaches such as micronization, solid dispersion, complexation, hydrotrophy, co-solvency, use of surfactant, sonocrystallization, particle size reduction, micro emulsion, nanosuspensions, cryogenic Techniques has been used to enhance the solubility of poorly water soluble drugs. In this review authors discussed about various Techniques used to enhance absorption and bio avilability of drugs and various patents available on solubility enhancement.