作者
Jin Jin, Marie‐Karelle Riviere, Xiaodong Luo, Yingwen Dong
发表日期
2020/11/10
来源
Statistics in Medicine
卷号
39
期号
25
页码范围
3459-3475
简介
Research in oncology has changed the focus from histological properties of tumors in a specific organ to a specific genomic aberration potentially shared by multiple cancer types. This motivates the basket trial, which assesses the efficacy of treatment simultaneously on multiple cancer types that have a common aberration. Although the assumption of homogeneous treatment effects seems reasonable given the shared aberration, in reality, the treatment effect may vary by cancer type, and potentially only a subgroup of the cancer types respond to the treatment. Various approaches have been proposed to increase the trial power by borrowing information across cancer types, which, however, tend to inflate the type I error rate. In this article, we review some representative Bayesian information borrowing methods for the analysis of early‐phase basket trials. We then propose a novel method called the Bayesian …
引用总数
20212022202320241476