作者
Sagi Abelson, Grace Collord, Stanley WK Ng, Omer Weissbrod, Netta Mendelson Cohen, Elisabeth Niemeyer, Noam Barda, Philip C Zuzarte, Lawrence Heisler, Yogi Sundaravadanam, Robert Luben, Shabina Hayat, Ting Ting Wang, Zhen Zhao, Iulia Cirlan, Trevor J Pugh, David Soave, Karen Ng, Calli Latimer, Claire Hardy, Keiran Raine, David Jones, Diana Hoult, Abigail Britten, John D McPherson, Mattias Johansson, Faridah Mbabaali, Jenna Eagles, Jessica K Miller, Danielle Pasternack, Lee Timms, Paul Krzyzanowski, Philip Awadalla, Rui Costa, Eran Segal, Scott V Bratman, Philip Beer, Sam Behjati, Inigo Martincorena, Jean CY Wang, Kristian M Bowles, J Ramón Quirós, Anna Karakatsani, Carlo La Vecchia, Antonia Trichopoulou, Elena Salamanca-Fernández, José M Huerta, Aurelio Barricarte, Ruth C Travis, Rosario Tumino, Giovanna Masala, Heiner Boeing, Salvatore Panico, Rudolf Kaaks, Alwin Krämer, Sabina Sieri, Elio Riboli, Paolo Vineis, Matthieu Foll, James McKay, Silvia Polidoro, Núria Sala, Kay-Tee Khaw, Roel Vermeulen, Peter J Campbell, Elli Papaemmanuil, Mark D Minden, Amos Tanay, Ran D Balicer, Nicholas J Wareham, Moritz Gerstung, John E Dick, Paul Brennan, George S Vassiliou, Liran I Shlush
发表日期
2018/7/19
期刊
Nature
卷号
559
期号
7714
页码范围
400-404
出版商
Nature Publishing Group UK
简介
The incidence of acute myeloid leukaemia (AML) increases with age and mortality exceeds 90% when diagnosed after age 65. Most cases arise without any detectable early symptoms and patients usually present with the acute complications of bone marrow failure. The onset of such de novo AML cases is typically preceded by the accumulation of somatic mutations in preleukaemic haematopoietic stem and progenitor cells (HSPCs) that undergo clonal expansion,. However, recurrent AML mutations also accumulate in HSPCs during ageing of healthy individuals who do not develop AML, a phenomenon referred to as age-related clonal haematopoiesis (ARCH), , , –. Here we use deep sequencing to analyse genes that are recurrently mutated in AML to distinguish between individuals who have a high risk of developing AML and those with benign ARCH. We analysed peripheral blood cells from 95 individuals that …
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S Abelson, G Collord, SWK Ng, O Weissbrod… - Nature, 2018