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Unreinforced masonry panels are often used as interior or exterior partitions in reinforced concrete frames. How infills affect the seismic performance of an RC building is an intricate issue since their exact role in the seismic load resistance is not yet clearly understood due to the interaction with the bounding frame. Assessing this role presents a challenge for structural engineers due to the variety and complexity of observed failure mechanisms and the lack of reliable methods able to capture these mechanisms. Furthermore, there is a lack of experimental data from large-scale dynamic tests of multi-story, multi-bay infilled frames to validate the analytical tools.