作者
Katherine H Thompson, Chris Orvig
发表日期
2003/5/9
来源
Science
卷号
300
期号
5621
页码范围
936-939
出版商
American Association for the Advancement of Science
简介
In biological systems metal ions promote responses that range from deficiency to toxicity. Some, such as iron and zinc, have a known optimal intake range for normal, healthy individuals. Metal ions contained within well-designed molecules already constitute a great boon for the medicinal pharmacopoeia. However, whether essential or not, the threshold for toxicity can be very low. One of the challenges of designing metal-based drugs is to balance the potential toxicity of an active formulation with the substantial positive impact of these increasingly common therapeutic and diagnostic aids.
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