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In this paper, our primary goal is to investigate the existence of solutions for an impulsive fractional integro-differential system (IFIDS) subject to boundary value conditions (BVC), utilizing the Caputo-Fabrizio operator (CFO). Through the application of fixed-point methodologies, we derive original insights into the existence of solutions. The final section of the study incorporates three numerical examples, serving to illustrate the practical application of the theoretical concepts introduced.