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In moving health and social service programs from planning into action, it is essential to understand the extent to which the knowledge gained from research should influence the actions taken by organizations and agencies that provide services (e.g., government, nongovernment organizations [NGOs]). The complexity of the challenges in translating lessons learned from science into different service settings, as well as into public policy, requires a multifaceted approach to accelerate the integration of research with practice. In this paper, the relationship between science and service is examined within the contexts of the scientific, health practice, and policy communities largely from a public sector perspective within the United States.