作者
Pyotr G Platonov, Anna I Castrini, Anneli Svensson, Morten K Christiansen, Thomas Gilljam, Henning Bundgaard, Trine Madsen, Tiina Heliö, Alex H Christensen, Meriam Aneq Åström, Jonas Carlson, Thor Edvardsen, Henrik K Jensen, Kristina H Haugaa, Jesper H Svendsen
发表日期
2020/12
期刊
EP Europace
卷号
22
期号
12
页码范围
1873-1879
出版商
Oxford University Press
简介
Aims
Women with arrhythmogenic right ventricular cardiomyopathy (ARVC) are at relatively lower risk of ventricular arrhythmias (VAs) than men, but the physical burden associated with pregnancy on VA risk remains insufficiently studied. We aimed to assess the risk of VA in relation to pregnancies in women with ARVC.
Methods and results
We included 199 females with definite ARVC (n = 121) and mutation-positive family members without ascertained ARVC diagnosis (n = 78), of whom 120 had at least one childbirth. Ventricular arrhythmia-free survival after the latest childbirth was compared between women with one (n = 20), two (n = 67), and three or more (n = 37) childbirths. Cumulative probability of VA for each pregnancy (n = 261) was assessed from conception through 2 years after childbirth and compared between those pregnancies that occurred before …
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PG Platonov, AI Castrini, A Svensson, MK Christiansen… - EP Europace, 2020