作者
Tanja Charlotte Frederiksen, Morten Krogh Christiansen, Pernille Charmoth Østergaard, Per Hove Thomsen, Claus Graff, Loa Clausen, Henrik Kjærulf Jensen
发表日期
2018/8
期刊
Circulation: Arrhythmia and Electrophysiology
卷号
11
期号
8
页码范围
e005995
出版商
Lippincott Williams & Wilkins
简介
Background
The literature contains several cases of anorexia nervosa (AN) patients with prolonged QTc interval. However, the risk of prolonged QTc interval is controversial and the risk of cardiac events in AN patients has yet to be investigated.
Methods
We estimated the difference in mean QTc interval and relative risk of borderline prolonged QTc (>440 ms) and prolonged QTc (>460 ms) between 430 adult women AN patients and 123 healthy controls using 3 correction formulas. In a follow-up study, we estimated the risk of a primary end point (a composite of ventricular tachycardia, aborted cardiac arrest, and cardiac arrest) in AN patients compared with a population-based cohort derived from the Danish Civil Register.
Results
Mean QTc for AN patients was 408 ms (Hodges), 402 ms (Fridericia), and 399 ms (Bazett). Hodges’ found a slightly increased mean QTc (6.8 ms, 95% confidence interval, 1.6–12.0; P=0 …
学术搜索中的文章
QTc interval and risk of cardiac events in adults with anorexia nervosa: a long-term follow-up study
TC Frederiksen, M Krogh Christiansen… - Circulation: Arrhythmia and Electrophysiology, 2018