作者
Sasimanas Unajak, Mudjekeewis D Santos, Jun-ichi Hikima, Tae-Sung Jung, Hidehiro Kondo, Ikuo Hirono, Takashi Aoki
发表日期
2011/8/1
期刊
Fish & shellfish immunology
卷号
31
期号
2
页码范围
202-211
出版商
Academic Press
简介
Pattern recognition receptors (PRRs) are involved in the effective innate defense against several microbes. Here, we identified a nucleotide-oligomerization domain (NOD)-like receptor subfamily C (NLRC) from Japanese flounder (Paralichthys olivaceus). Full-length transcript of JfNLRC is composed of 3976 bp encoding a protein of 1175 deduced amino acid residues. The presence of a signature nucleotide-binding domain (NACHT) and leucine-rich repeated domain (LRR) suggested that the protein is a member of the NLR family. Interestingly, its C-terminus presents an extra PRY/SPRY (B30.2) domain similar to fish in the Trim (finTrim) family. A phylogenic tree of JfNLRC revealed that full-length JfNLRC diverged from the NOD1 and NOD2 clusters, and the NACHT domain in JfNLRC was clustered within the NLRC3 group. Stimulation by formalin-killed Edwardsiella tarda, Streptococcus iniae, and …
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S Unajak, MD Santos, J Hikima, TS Jung, H Kondo… - Fish & shellfish immunology, 2011