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TO THE EDITOR: Vrshek-Schallhorn et al. dispute our conclusion that historic candidate gene-by-environment (G3E) hypotheses were incorrect, criticizing the measures of environmental stressors we employed. We appreciate the opportunity to respond to their points. We agree with their point that measures of environment are important, as we emphasized in our article (1). Our results demonstrate that both interpersonal and noninterpersonal environmental measures influence depression liability (see Table S6 in the online supplement to our article). The additive effects of these environmental measures replicate previous findings that a variety of stressors affect depression liability. However, Vrshek-Schallhorn et al. suggest that the measures we used are completely obscuring real candidate G3E effects. Below, we argue that this cannot be the case and that several of their comments are inaccurate. They refer to the …