作者
David Murrugarra, Alan Veliz-Cuba, Boris Aguilar, Seda Arat, Reinhard Laubenbacher
发表日期
2012/12
期刊
EURASIP Journal on Bioinformatics and Systems Biology
卷号
2012
页码范围
1-11
出版商
Springer International Publishing
简介
Modeling stochasticity in gene regulatory networks is an important and complex problem in molecular systems biology. To elucidate intrinsic noise, several modeling strategies such as the Gillespie algorithm have been used successfully. This article contributes an approach as an alternative to these classical settings. Within the discrete paradigm, where genes, proteins, and other molecular components of gene regulatory networks are modeled as discrete variables and are assigned as logical rules describing their regulation through interactions with other components. Stochasticity is modeled at the biological function level under the assumption that even if the expression levels of the input nodes of an update rule guarantee activation or degradation there is a probability that the process will not occur due to stochastic effects. This approach allows a finer analysis of discrete models and provides a natural …
引用总数
20122013201420152016201720182019202020212022202320245581110561155491
学术搜索中的文章
D Murrugarra, A Veliz-Cuba, B Aguilar, S Arat… - EURASIP Journal on Bioinformatics and Systems …, 2012