作者
Adam H Dyer, Claire Murphy, Brian Lawlor, Sean P Kennelly, Ricardo Segurado, Sean Kennelly, Marcel GM Olde Rikkert, Robert Howard, Florence Pasquier, Anne Börjesson-Hanson, Magda Tsolaki, Ugo Lucca, D William Molloy, Robert Coen, Matthias W Riepe, János Kálmán, Rose Anne Kenny, Fiona Cregg, Sarah O'Dwyer, Cathal Walsh, Jessica Adams, Rita Banzi, Laetitia Breuilh, Leslie Daly, Suzanne Hendrix, Paul Aisen, Siobhan Gaynor, Ali Sheikhi, Diana G Taekema, Frans R Verhey, Raffaello Nemni, Flavio Nobili, Massimo Franceschi, Giovanni Frisoni, Orazio Zanetti, Anastasia Konsta, Orologas Anastasios, Styliani Nenopoulou, Fani Tsolaki-Tagaraki, Magdolna Pakaski, Olivier Dereeper, Vincent de la Sayette, Olivier Sénéchal, Isabelle Lavenu, Agnès Devendeville, Gauthier Calais, Fiona Crawford, Michael Mullan, Pauline Aalten, Maria A Berglund, Jurgen A Claassen, Rianne A De Heus, Daan LK De Jong, Olivier Godefroy, Siobhan Hutchinson, Aikaterini Ioannou, Michael Jonsson, Annette Kent, Jürgen Kern, Petros Nemtsas, Minoa-Kalliopi Panidou, Laila Abdullah, Daniel Paris, Angelina M Santoso, Gerrita J van Spijker, Martha Spiliotou, Georgia Thomoglou, Anders Wallin
发表日期
2020/2/1
期刊
Journal of the American Medical Directors Association
卷号
21
期号
2
页码范围
194-200
出版商
Elsevier
简介
Objective
Benzodiazepines and related drugs (BDZRs) have been associated with an increased risk of Alzheimer's disease (AD) in later life. Despite this, it remains unclear whether ongoing BDZR use may further accelerate cognitive decline in those diagnosed with mild to moderate AD.
Design
This study was embedded within NILVAD, a randomized controlled trial of nilvadipine in mild to moderate AD. Cognition was measured at baseline and 18 months using the Alzheimer Disease Assessment Scale, Cognitive Subsection (ADAS-Cog). We assessed predictors of long-term BDZR use and analyzed the effect of ongoing BDZR use on ADAS-Cog scores at 18 months. Additionally, the impact of BDZR use on adverse events, incident delirium, and falls over 18-month follow-up was assessed adjusting for relevant covariates.
Setting and Participants
448 participants with mild to moderate AD recruited from 23 academic …
学术搜索中的文章
AH Dyer, C Murphy, B Lawlor, SP Kennelly… - Journal of the American Medical Directors Association, 2020