作者
Liam Townsend, Helen Fogarty, Adam Dyer, Ignacio Martin‐Loeches, Ciaran Bannan, Parthiban Nadarajan, Colm Bergin, Cliona O’Farrelly, Niall Conlon, Nollaig M Bourke, Soracha E Ward, Mary Byrne, Kevin Ryan, Niamh O’Connell, Jamie M O’Sullivan, Cliona Ni Cheallaigh, James S O’Donnell
发表日期
2021/4
期刊
Journal of Thrombosis and Haemostasis
卷号
19
期号
4
页码范围
1064-1070
简介
Background
Persistent fatigue, breathlessness, and reduced exercise tolerance have been reported following acute COVID‐19 infection. Although immuno‐thrombosis has been implicated in acute COVID‐19 pathogenesis, the biological mechanisms underpinning long COVID remain unknown. We hypothesized that pulmonary microvascular immuno‐thrombosis may be important in this context.
Methods
One hundred fifty COVID‐19 patients were reviewed at St James's Hospital Dublin between May and September 2020 at a median of 80.5 (range 44–155) days after initial diagnosis. These included patients hospitalized during initial illness (n = 69) and others managed entirely as out‐patients (n = 81). Clinical examination, chest x‐ray, and 6‐min walk tests were performed. In addition, a range of coagulation and inflammatory markers were assessed.
Results
Increased D‐dimer levels (>500 ng/ml) were …
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L Townsend, H Fogarty, A Dyer, I Martin‐Loeches… - Journal of Thrombosis and Haemostasis, 2021