作者
Paul Guedeney, Bimmer E Claessen, Roxana Mehran, Gary S Mintz, Mengdan Liu, Sabato Sorrentino, Gennaro Giustino, Serdar Farhan, Martin B Leon, Patrick W Serruys, Pieter C Smits, Clemens von Birgelen, Ziad A Ali, Philippe Généreux, Björn Redfors, Mahesh V Madhavan, Ori Ben-Yehuda, Gregg W Stone
发表日期
2020/6/22
期刊
Cardiovascular Interventions
卷号
13
期号
12
页码范围
1417-1428
出版商
American College of Cardiology Foundation
简介
Objectives
The aim of this study was to evaluate the long-term impact of coronary artery calcification (CAC) on outcomes after percutaneous coronary intervention and the respective performance of first- and second-generation drug-eluting stents (DES).
Background
Whether contemporary DES have improved the long-term prognosis after percutaneous coronary intervention in lesions with severe CAC is unknown.
Methods
Individual patient data were pooled from 18 randomized trials evaluating DES, categorized according to the presence of angiography core laboratory–confirmed moderate or severe CAC. Major endpoints were the patient-oriented composite endpoint (death, myocardial infarction [MI], or any revascularization) and the device-oriented composite endpoint of target lesion failure (cardiac death, target vessel MI, or ischemia-driven target lesion revascularization). Multivariate Cox proportional …
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P Guedeney, BE Claessen, R Mehran, GS Mintz, M Liu… - Cardiovascular Interventions, 2020