作者
Saeideh Mazloomzadeh, Shiva Khaleghparast, Behshid Ghadrdoost, Mostafa Mousavizadeh, Mohammad Reza Baay, Feridoun Noohi, Hamidreza Sharifnia, Arezoo Ahmadi, Sasan Tavan, Nasser Malekpour Alamdari, Mohammad Fathi, Mahshid Soleimanzadeh, Mostafa Mostafa, Navid Davoody, Maryam Zarinsadaf, Sara Tayyebi, Fahimeh Farrokhzadeh, Faeze Nezamabadi, Esmaeil Soomari, Parham Sadeghipour, Azita H Talasaz, Farid Rashidi, Babak Sharif-Kashani, Mohammad Taghi Beigmohammadi, Mohsen Farrokhpour, Seyed Hashem Sezavar, Pooya Payandemehr, Ali Dabbagh, Keivan Gohari Moghadam, Sepehr Jamalkhani, Hossein Khalili, Mahdi Yadollahzadeh, Taghi Riahi, Parisa Rezaeifar, Ouria Tahamtan, Samira Matin, Atefeh Abedini, Somayeh Lookzadeh, Hamid Rahmani, Elnaz Zoghi, Keyhan Mohammadi, Pardis Sadeghipour, Homa Abri, Sanaz Tabrizi, Seyed Masoud Mousavian, Shaghayegh Shahmirzaei, Hooman Bakhshandeh, Ahmad Amin, Farnaz Rafiee, Elahe Baghizadeh, Bahram Mohebbi, Seyed Ehsan Parhizgar, Rasoul Aliannejad, Vahid Eslami, Alireza Kashefizadeh, Hessam Kakavand, Seyed Hossein Hosseini, Shadi Shafaghi, Samrand Fattah Ghazi, Atabak Najafi, David Jimenez, Aakriti Gupta, Mahesh V Madhavan, Sanjum S Sethi, Sahil A Parikh, Manuel Monreal, Naser Hadavand, Alireza Hajighasemi, Majid Maleki, Saeed Sadeghian, Gregory Piazza, Ajay J Kirtane, Benjamin W Van Tassell, Paul P Dobesh, Gregg W Stone, Gregory YH Lip, Harlan M Krumholz, Samuel Z Goldhaber, Behnood Bikdeli, INSPIRATION Investigators
发表日期
2021/4/27
期刊
Jama
卷号
325
期号
16
页码范围
1620-1630
出版商
American Medical Association
简介
Importance
Thrombotic events are commonly reported in critically ill patients with COVID-19. Limited data exist to guide the intensity of antithrombotic prophylaxis.
Objective
To evaluate the effects of intermediate-dose vs standard-dose prophylactic anticoagulation among patients with COVID-19 admitted to the intensive care unit (ICU).
Design, Setting, and Participants
Multicenter randomized trial with a 2 × 2 factorial design performed in 10 academic centers in Iran comparing intermediate-dose vs standard-dose prophylactic anticoagulation (first hypothesis) and statin therapy vs matching placebo (second hypothesis; not reported in this article) among adult patients admitted to the ICU with COVID-19. Patients were recruited between July 29, 2020, and November 19, 2020. The final follow-up date for the 30-day primary outcome was December 19, 2020.
Interventions
Intermediate-dose (enoxaparin, 1 mg/kg daily) (n …
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S Mazloomzadeh, S Khaleghparast, B Ghadrdoost… - Jama, 2021