作者
Aakriti Gupta, Mahesh V Madhavan, Timothy J Poterucha, Ersilia M DeFilippis, Jessica A Hennessey, Bjorn Redfors, Christina Eckhardt, Behnood Bikdeli, Jonathan Platt, Ani Nalbandian, Pierre Elias, Matthew J Cummings, Shayan N Nouri, Matthew Lawlor, Lauren S Ranard, Jianhua Li, Claudia Boyle, Raymond Givens, Daniel Brodie, Harlan M Krumholz, Gregg W Stone, Sanjum S Sethi, Daniel Burkhoff, Nir Uriel, Allan Schwartz, Martin B Leon, Ajay J Kirtane, Elaine Y Wan, Sahil A Parikh
发表日期
2021/2/26
期刊
Nature communications
卷号
12
期号
1
页码范围
1325
出版商
Nature Publishing Group UK
简介
The coronavirus disease 2019 (COVID-19) can result in a hyperinflammatory state, leading to acute respiratory distress syndrome (ARDS), myocardial injury, and thrombotic complications, among other sequelae. Statins, which are known to have anti-inflammatory and antithrombotic properties, have been studied in the setting of other viral infections, but their benefit has not been assessed in COVID-19. This is a retrospective analysis of patients admitted with COVID-19 from February 1st through May 12th, 2020 with study period ending on June 11th, 2020. Antecedent statin use was assessed using medication information available in the electronic medical record. We constructed a multivariable logistic regression model to predict the propensity of receiving statins, adjusting for baseline sociodemographic and clinical characteristics, and outpatient medications. The primary endpoint includes in-hospital mortality …
引用总数
20202021202220232024460663210
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