作者
Tiffany YT Hsu, Kristin M D'Silva, Naomi J Patel, Jiaqi Wang, Alisa A Mueller, Xiaoqing Fu, Lauren Prisco, Lily Martin, Kathleen MM Vanni, Alessandra Zaccardelli, Claire Cook, Hyon K Choi, Yuqing Zhang, Ellen M Gravallese, Zachary S Wallace, Jeffrey A Sparks
发表日期
2021/9/1
期刊
The Lancet Rheumatology
卷号
3
期号
9
页码范围
e638-e647
出版商
Elsevier
简介
Background
COVID-19 can induce a hyperinflammatory state, which might lead to poor clinical outcomes. We aimed to assess whether patients with a systemic rheumatic disease might be at increased risk for hyperinflammation and respiratory failure from COVID-19.
Methods
We did a retrospective, comparative cohort study of patients aged 18 years or older admitted to hospital with PCR-confirmed COVID-19 at Mass General Brigham (Boston, USA). We identified patients by a search of electronic health records and matched patients with a systemic rheumatic disease 1:5 to comparators. We compared individual laboratory results by case status and extracted laboratory results and COVID-19 outcomes for each participant. We calculated the COVID-19-associated hyperinflammation score (cHIS), a composite of six domains (a score of ≥2 indicating hyperinflammation) and used logistic regression to estimate odds …
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TYT Hsu, KM D'Silva, NJ Patel, J Wang, AA Mueller… - The Lancet Rheumatology, 2021