作者
Zhonghe Ke, Amita Vaidya, Jill Ascher, Andrei Seluanov, Vera Gorbunova
发表日期
2014/1/1
期刊
Journal of the American Association for Laboratory Animal Science
卷号
53
期号
1
页码范围
89-91
出版商
American Association for Laboratory Animal Science
简介
The naked mole rat (NMR) is a small eusocial rodent. Because of its remarkable longevity (maximal lifespan, 32 y) and resistance to cancer, the NMR has emerged as a valuable model for aging and cancer research. However, breeding NMR can be difficult. Here, we report the successful introduction and acceptance of pups into a foreign colony with existing pups of different ages. Among the 7 NMR colonies in our satellite facility, one had a consistently poor record of pup viability, with nearly 100% preweaning mortality in multiple litters born over the course of 2 y. The queen of this colony gave birth to 18 pups in January 2013; by 2 d after parturition, it was evident that the pups were not receiving sufficient nourishment. To salvage the litter, the most vigorous pups were cross-fostered to another queen that had recently given birth. On postparturition day 1 (PD1), two pups from the poorly nourished donor litter were …
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Z Ke, A Vaidya, J Ascher, A Seluanov, V Gorbunova - Journal of the American Association for Laboratory …, 2014