作者
Aimin Tang, Zhifeng Chen, Kara S Cox, Hua-Poo Su, Cheryl Callahan, Arthur Fridman, Lan Zhang, Sangita B Patel, Pedro J Cejas, Ryan Swoyer, Sinoeun Touch, Michael P Citron, Dhanasekaran Govindarajan, Bin Luo, Michael Eddins, John C Reid, Stephen M Soisson, Jennifer Galli, Dai Wang, Zhiyun Wen, Gwendolyn J Heidecker, Danilo R Casimiro, Daniel J DiStefano, Kalpit A Vora
发表日期
2019/9/12
期刊
Nature communications
卷号
10
期号
1
页码范围
4153
出版商
Nature Publishing Group UK
简介
Respiratory syncytial virus (RSV) infection is the leading cause of hospitalization and infant mortality under six months of age worldwide; therefore, the prevention of RSV infection in all infants represents a significant unmet medical need. Here we report the isolation of a potent and broadly neutralizing RSV monoclonal antibody derived from a human memory B-cell. This antibody, RB1, is equipotent on RSV A and B subtypes, potently neutralizes a diverse panel of clinical isolates in vitro and demonstrates in vivo protection. It binds to a highly conserved epitope in antigenic site IV of the RSV fusion glycoprotein. RB1 is the parental antibody to MK-1654 which is currently in clinical development for the prevention of RSV infection in infants.
学术搜索中的文章
A Tang, Z Chen, KS Cox, HP Su, C Callahan… - Nature communications, 2019