作者
Masahiro Yoshida, Kaylee B Worlock, Ni Huang, Rik GH Lindeboom, Colin R Butler, Natsuhiko Kumasaka, Cecilia Dominguez Conde, Lira Mamanova, Liam Bolt, Laura Richardson, Krzysztof Polanski, Elo Madissoon, Josephine L Barnes, Jessica Allen-Hyttinen, Eliz Kilich, Brendan C Jones, Angus De Wilton, Anna Wilbrey-Clark, Waradon Sungnak, J Patrick Pett, Juliane Weller, Elena Prigmore, Henry Yung, Puja Mehta, Aarash Saleh, Anita Saigal, Vivian Chu, Jonathan M Cohen, Clare Cane, Aikaterini Iordanidou, Soichi Shibuya, Ann-Kathrin Reuschl, Iván T Herczeg, A Christine Argento, Richard G Wunderink, Sean B Smith, Taylor A Poor, Catherine A Gao, Jane E Dematte, NU SCRIPT Study Investigators Budinger GR Scott 9 Donnelly Helen K. 10 Markov Nikolay S. 10 Lu Ziyan 10, Gary Reynolds, Muzlifah Haniffa, Georgina S Bowyer, Matthew Coates, Menna R Clatworthy, Fernando J Calero-Nieto, Berthold Göttgens, Christopher O’Callaghan, Neil J Sebire, Clare Jolly, Paolo De Coppi, Claire M Smith, Alexander V Misharin, Sam M Janes, Sarah A Teichmann, Marko Z Nikolić, Kerstin B Meyer
发表日期
2022/2/10
期刊
Nature
卷号
602
期号
7896
页码范围
321-327
出版商
Nature Publishing Group UK
简介
It is not fully understood why COVID-19 is typically milder in children, –. Here, to examine the differences between children and adults in their response to SARS-CoV-2 infection, we analysed paediatric and adult patients with COVID-19 as well as healthy control individuals (total n = 93) using single-cell multi-omic profiling of matched nasal, tracheal, bronchial and blood samples. In the airways of healthy paediatric individuals, we observed cells that were already in an interferon-activated state, which after SARS-CoV-2 infection was further induced especially in airway immune cells. We postulate that higher paediatric innate interferon responses restrict viral replication and disease progression. The systemic response in children was characterized by increases in naive lymphocytes and a depletion of natural killer cells, whereas, in adults, cytotoxic T cells and interferon-stimulated subpopulations were significantly …
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M Yoshida, KB Worlock, N Huang, RGH Lindeboom… - Nature, 2022