Discovery of Q203, a potent clinical candidate for the treatment of tuberculosis K Pethe, P Bifani, J Jang, S Kang, S Park, S Ahn, J Jiricek, J Jung, ... Nature medicine 19 (9), 1157-1160, 2013 | 609 | 2013 |
The protonmotive force is required for maintaining ATP homeostasis and viability of hypoxic, nonreplicating Mycobacterium tuberculosis SPS Rao, S Alonso, L Rand, T Dick, K Pethe Proceedings of the National Academy of Sciences 105 (33), 11945-11950, 2008 | 601 | 2008 |
Proteasome inhibition for treatment of leishmaniasis, Chagas disease and sleeping sickness S Khare, AS Nagle, A Biggart, YH Lai, F Liang, LC Davis, SW Barnes, ... Nature 537 (7619), 229-233, 2016 | 405 | 2016 |
A chemical genetic screen in Mycobacterium tuberculosis identifies carbon-source-dependent growth inhibitors devoid of in vivo efficacy K Pethe, PC Sequeira, S Agarwalla, K Rhee, K Kuhen, WY Phong, V Patel, ... Nature communications 1 (1), 57, 2010 | 320 | 2010 |
Nutrient-starved, non-replicating Mycobacterium tuberculosis requires respiration, ATP synthase and isocitrate lyase for maintenance of ATP homeostasis and … M Gengenbacher, SPS Rao, K Pethe, T Dick Microbiology 156 (1), 81-87, 2010 | 308 | 2010 |
Use of proteomics to identify novel virulence determinants that are required for Edwardsiella tarda pathogenesis PS Srinivasa Rao, Y Yamada, YP Tan, KY Leung Molecular microbiology 53 (2), 573-586, 2004 | 273 | 2004 |
The natural product cyclomarin kills Mycobacterium tuberculosis by targeting the ClpC1 subunit of the caseinolytic protease EK Schmitt, M Riwanto, V Sambandamurthy, S Roggo, C Miault, ... Angewandte Chemie International Edition 26 (50), 5889-5891, 2011 | 206 | 2011 |
Prioritizing genomic drug targets in pathogens: application to Mycobacterium tuberculosis S Hasan, S Daugelat, PSS Rao, M Schreiber PLoS computational biology 2 (6), e61, 2006 | 189 | 2006 |
Opsonized Virulent Edwardsiella tarda Strains Are Able To Adhere to and Survive and Replicate within Fish Phagocytes but Fail To Stimulate Reactive Oxygen … PSS Rao, TM Lim, KY Leung Infection and immunity 69 (9), 5689-5697, 2001 | 184 | 2001 |
A Type III Secretion System Is Required for Aeromonas hydrophila AH-1 Pathogenesis HB Yu, PSS Rao, HC Lee, S Vilches, S Merino, JM Tomas, KY Leung Infection and immunity 72 (3), 1248-1256, 2004 | 176 | 2004 |
Indolcarboxamide is a preclinical candidate for treating multidrug-resistant tuberculosis SPS Rao, SB Lakshminarayana, RR Kondreddi, M Herve, LR Camacho, ... Science translational medicine 5 (214), 214ra168-214ra168, 2013 | 166 | 2013 |
Comprehensive physicochemical, pharmacokinetic and activity profiling of anti-TB agents SB Lakshminarayana, TB Huat, PC Ho, UH Manjunatha, V Dartois, T Dick, ... Journal of Antimicrobial Chemotherapy 70 (3), 857-867, 2015 | 157 | 2015 |
Functional Genomics Approach to the Identification of Virulence Genes Involved in Edwardsiella tarda Pathogenesis PS Srinivasa Rao, TM Lim, KY Leung Infection and Immunity 71 (3), 1343-1351, 2003 | 149 | 2003 |
Triacylglycerol Utilization Is Required for Regrowth of In Vitro Hypoxic Nonreplicating Mycobacterium bovis Bacillus Calmette-Guerin KL Low, PSS Rao, G Shui, AK Bendt, K Pethe, T Dick, MR Wenk Journal of bacteriology 191 (16), 5037-5043, 2009 | 148 | 2009 |
The effectiveness of a commercial microbial product in poorly prepared tiger shrimp, Penaeus monodon (Fabricius), ponds M Shariff, FM Yusoff, TN Devaraja, PSS Rao Aquaculture Research 32 (3), 181-187, 2001 | 144 | 2001 |
A major catalase (KatB) that is required for resistance to H2O2 and phagocyte-mediated killing in Edwardsiella tarda PS Srinivasa Rao, Y Yamada, KY Leung Microbiology 149 (9), 2635-2644, 2003 | 143 | 2003 |
A High-Throughput Screen To Identify Inhibitors of ATP Homeostasis in Non-replicating Mycobacterium tuberculosis PA Mak, SPS Rao, M Ping Tan, X Lin, J Chyba, J Tay, SH Ng, BH Tan, ... ACS chemical biology 7 (7), 1190-1197, 2012 | 134 | 2012 |
Structural Basis of Mycobacterial Inhibition by Cyclomarin A D Vasudevan, SPS Rao, CG Noble Journal of Biological Chemistry, 2013 | 129 | 2013 |
Direct inhibitors of InhA are active against Mycobacterium tuberculosis UH Manjunatha, SP S. Rao, RR Kondreddi, CG Noble, LR Camacho, ... Science translational medicine 7 (269), 269ra3-269ra3, 2015 | 126 | 2015 |
A novel F420‐dependent anti‐oxidant mechanism protects Mycobacterium tuberculosis against oxidative stress and bactericidal agents M Gurumurthy, M Rao, T Mukherjee, SPS Rao, HI Boshoff, T Dick, ... Molecular microbiology 87 (4), 744-755, 2013 | 118 | 2013 |