| Orally bioavailable small-molecule inhibitor of transcription factor Stat3 regresses human breast and lung cancer xenografts X Zhang, P Yue, BDG Page, T Li, W Zhao, AT Namanja, D Paladino, ... Proceedings of the National Academy of Sciences 109 (24), 9623-9628, 2012 | 372 | 2012 |
| Combined STAT3 and BCR-ABL1 inhibition induces synthetic lethality in therapy-resistant chronic myeloid leukemia AM Eiring, BDG Page, IL Kraft, CC Mason, NA Vellore, D Resetca, ... Leukemia 29 (3), 586-597, 2015 | 144 | 2015 |
| Signal transducer and activator of transcription 3 inhibitors: a patent review BDG Page, DP Ball, PT Gunning Expert opinion on therapeutic patents 21 (1), 65-83, 2011 | 134 | 2011 |
| Molecular disruption of oncogenic signal transducer and activator of transcription 3 (STAT3) protein S Fletcher, JA Drewry, VM Shahani, BDG Page, PT Gunning Biochemistry and Cell Biology 87 (6), 825-833, 2009 | 133 | 2009 |
| Targeting SAMHD1 with the Vpx protein to improve cytarabine therapy for hematological malignancies N Herold, SG Rudd, L Ljungblad, K Sanjiv, IH Myrberg, CBJ Paulin, ... Nature medicine 23 (2), 256-263, 2017 | 128 | 2017 |
| Potent targeting of the STAT3 protein in brain cancer stem cells: a promising route for treating glioblastoma S Haftchenary, HA Luchman, AO Jouk, AJ Veloso, BDG Page, XR Cheng, ... ACS medicinal chemistry letters 4 (11), 1102-1107, 2013 | 126 | 2013 |
| Crystal structure, biochemical and cellular activities demonstrate separate functions of MTH1 and MTH2 M Carter, AS Jemth, A Hagenkort, BDG Page, R Gustafsson, JJ Griese, ... Nature communications 6 (1), 7871, 2015 | 123 | 2015 |
| Disruption of transcriptionally active Stat3 dimers with non-phosphorylated, salicylic acid-based small molecules: potent in vitro and tumor cell activities S Fletcher, J Singh, X Zhang, P Yue, BDG Page, S Sharmeen, ... Chembiochem: a European journal of chemical biology 10 (12), 1959, 2009 | 122 | 2009 |
| Small molecule STAT5-SH2 domain inhibitors exhibit potent antileukemia activity BDG Page, H Khoury, RC Laister, S Fletcher, M Vellozo, A Manzoli, P Yue, ... Journal of medicinal chemistry 55 (3), 1047-1055, 2012 | 119 | 2012 |
| NUDT15 hydrolyzes 6-thio-deoxyGTP to mediate the anticancer efficacy of 6-thioguanine NCK Valerie, A Hagenkort, BDG Page, G Masuyer, D Rehling, M Carter, ... Cancer research 76 (18), 5501-5511, 2016 | 113 | 2016 |
| N-Aryl-substituted 3-(β-D-glucopyranosyloxy)-2-methyl-4 (1 H)-pyridinones as agents for Alzheimer's therapy LE Scott, M Telpoukhovskaia, C Rodríguez-Rodríguez, M Merkel, ... Chemical Science 2 (4), 642-648, 2011 | 87 | 2011 |
| Identification of a non-phosphorylated, cell permeable, small molecule ligand for the Stat3 SH2 domain BDG Page, S Fletcher, P Yue, Z Li, X Zhang, S Sharmeen, A Datti, ... Bioorganic & medicinal chemistry letters 21 (18), 5605-5609, 2011 | 75 | 2011 |
| Targeted NUDT5 inhibitors block hormone signaling in breast cancer cells BDG Page, NCK Valerie, RHG Wright, O Wallner, R Isaksson, M Carter, ... Nature communications 9 (1), 250, 2018 | 73 | 2018 |
| An activatable multimodal/multifunctional nanoprobe for direct imaging of intracellular drug delivery RN Mitra, M Doshi, X Zhang, JC Tyus, N Bengtsson, S Fletcher, ... Biomaterials 33 (5), 1500-1508, 2012 | 69 | 2012 |
| Antagonism of the Stat3–Stat3 protein dimer with salicylic acid based small molecules S Fletcher, BDG Page, X Zhang, P Yue, ZH Li, S Sharmeen, J Singh, ... ChemMedChem 6 (8), 1459-1470, 2011 | 68 | 2011 |
| STAT3 pathway regulates lung-derived brain metastasis initiating cell capacity through miR-21 activation M Singh, N Garg, C Venugopal, R Hallett, T Tokar, N McFarlane, ... Oncotarget 6 (29), 27461, 2015 | 62 | 2015 |
| Irreversible TrxR1 inhibitors block STAT3 activity and induce cancer cell death S Busker, W Qian, M Haraldsson, B Espinosa, L Johansson, S Attarha, ... Science advances 6 (12), eaax7945, 2020 | 60 | 2020 |
| STAT3 activity is necessary and sufficient for the development of immunemediated myocarditis in mice and promotes progression to dilated cardiomyopathy A Camporeale, F Marino, A Papageorgiou, P Carai, S Fornero, S Fletcher, ... EMBO molecular medicine 5 (4), 572-590, 2013 | 55 | 2013 |
| Dynamic reprogramming of signaling upon met inhibition reveals a mechanism of drug resistance in gastric cancer AZ Lai, S Cory, H Zhao, M Gigoux, A Monast, MC Guiot, S Huang, ... Science signaling 7 (322), ra38-ra38, 2014 | 47 | 2014 |
| TSLP as druggable target–A silver-lining for atopic diseases? PP Adhikary, Z Tan, BDG Page, S Hedtrich Pharmacology & Therapeutics 217, 107648, 2021 | 45 | 2021 |
