Ribozyme rescue of photoreceptor cells in a transgenic rat model of autosomal dominant retinitis pigmentosa AS Lewin, KA Drenser, WW Hauswirth, S Nishikawa, D Yasumura, ... Nature medicine 4 (8), 967-971, 1998 | 519 | 1998 |
High-efficiency transduction of the mouse retina by tyrosine-mutant AAV serotype vectors H Petrs-Silva, A Dinculescu, Q Li, SH Min, V Chiodo, JJ Pang, L Zhong, ... Molecular therapy 17 (3), 463-471, 2009 | 491 | 2009 |
Dysregulated autophagy in the RPE is associated with increased susceptibility to oxidative stress and AMD SK Mitter, C Song, X Qi, H Mao, H Rao, D Akin, A Lewin, M Grant, ... Autophagy 10 (11), 1989-2005, 2014 | 453 | 2014 |
A comprehensive review of retinal gene therapy SE Boye, SL Boye, AS Lewin, WW Hauswirth Molecular therapy 21 (3), 509-519, 2013 | 344 | 2013 |
Intrastriatal rAAV-mediated delivery of anti-huntingtin shRNAs induces partial reversal of disease progression in R6/1 Huntington's disease transgenic mice E Rodriguez-Lebron, EM Denovan-Wright, K Nash, AS Lewin, RJ Mandel Molecular therapy 12 (4), 618-633, 2005 | 330 | 2005 |
Gene therapy rescues photoreceptor blindness in dogs and paves the way for treating human X-linked retinitis pigmentosa WA Beltran, AV Cideciyan, AS Lewin, S Iwabe, H Khanna, A Sumaroka, ... Proceedings of the National Academy of Sciences 109 (6), 2132-2137, 2012 | 317 | 2012 |
Rescue of a mitochondrial deficiency causing Leber hereditary optic neuropathy J Guy, X Qi, F Pallotti, EA Schon, G Manfredi, V Carelli, A Martinuzzi, ... Annals of Neurology: Official Journal of the American Neurological …, 2002 | 312 | 2002 |
Novel properties of tyrosine-mutant AAV2 vectors in the mouse retina H Petrs-Silva, A Dinculescu, Q Li, WT Deng, J Pang, SH Min, V Chiodo, ... Molecular Therapy 19 (2), 293-301, 2011 | 305 | 2011 |
Restoration of visual function in P23H rhodopsin transgenic rats by gene delivery of BiP/Grp78 MS Gorbatyuk, T Knox, MM LaVail, OS Gorbatyuk, SM Noorwez, ... Proceedings of the National Academy of Sciences 107 (13), 5961-5966, 2010 | 298 | 2010 |
SOD2 knockdown mouse model of early AMD V Justilien, JJ Pang, K Renganathan, X Zhan, JW Crabb, SR Kim, ... Investigative ophthalmology & visual science 48 (10), 4407-4420, 2007 | 277 | 2007 |
Ribozyme rescue of photoreceptor cells in P23H transgenic rats: long-term survival and late-stage therapy MM LaVail, D Yasumura, MT Matthes, KA Drenser, JG Flannery, AS Lewin, ... Proceedings of the National Academy of Sciences 97 (21), 11488-11493, 2000 | 265 | 2000 |
In vivo RNAi-mediated α-synuclein silencing induces nigrostriatal degeneration OS Gorbatyuk, S Li, K Nash, M Gorbatyuk, AS Lewin, LF Sullivan, ... Molecular Therapy 18 (8), 1450-1457, 2010 | 238 | 2010 |
[48] Production and purification of recombinant adeno-associated virus WW Hauswirth, AS Lewin, S Zolotukhin, N Muzyczka Methods in enzymology 316, 743-761, 2000 | 207 | 2000 |
Ribozyme gene therapy: applications for molecular medicine AS Lewin, WW Hauswirth Trends in molecular medicine 7 (5), 221-228, 2001 | 203 | 2001 |
Glucose regulated protein 78 diminishes α-synuclein neurotoxicity in a rat model of Parkinson disease MS Gorbatyuk, A Shabashvili, W Chen, C Meyers, LF Sullivan, M Salganik, ... Molecular Therapy 20 (7), 1327-1337, 2012 | 201 | 2012 |
ACE2 and Ang-(1-7) confer protection against development of diabetic retinopathy A Verma, Z Shan, B Lei, L Yuan, X Liu, T Nakagawa, MB Grant, AS Lewin, ... Molecular therapy 20 (1), 28-36, 2012 | 197 | 2012 |
Mitochondrial oxidative stress in the retinal pigment epithelium (RPE) led to metabolic dysfunction in both the RPE and retinal photoreceptors EE Brown, AJ DeWeerd, CJ Ildefonso, AS Lewin, JD Ash Redox biology 24, 101201, 2019 | 190 | 2019 |
Gene delivery to mitochondria by targeting modified adenoassociated virus suppresses Leber’s hereditary optic neuropathy in a mouse model H Yu, RD Koilkonda, TH Chou, V Porciatti, SS Ozdemir, V Chiodo, ... Proceedings of the National Academy of Sciences 109 (20), E1238-E1247, 2012 | 184 | 2012 |
Mitochondrial protein nitration primes neurodegeneration in experimental autoimmune encephalomyelitis X Qi, AS Lewin, L Sun, WW Hauswirth, J Guy Journal of Biological Chemistry 281 (42), 31950-31962, 2006 | 168 | 2006 |
Citrate Synthase Encoded by the CIT2 Gene of Saccharomyces cerevisiae Is Peroxisomal AS Lewin, V Hines, GM Small Molecular and Cellular Biology 10 (4), 1399-1405, 1990 | 151 | 1990 |