| A new gene set identifies senescent cells and predicts senescence-associated pathways across tissues D Saul, RL Kosinsky, EJ Atkinson, ML Doolittle, X Zhang, NK LeBrasseur, ... Nature communications 13 (1), 4827, 2022 | 234 | 2022 |
| Epigenetics of aging and aging-associated diseases D Saul, RL Kosinsky International journal of molecular sciences 22 (1), 401, 2021 | 154 | 2021 |
| Histone deacetylase class-I inhibition promotes epithelial gene expression in pancreatic cancer cells in a BRD4-and MYC-dependent manner VK Mishra, F Wegwitz, RL Kosinsky, M Sen, R Baumgartner, T Wulff, ... Nucleic acids research 45 (11), 6334-6349, 2017 | 84 | 2017 |
| ARID1A facilitates KRAS signaling-regulated enhancer activity in an AP1-dependent manner in colorectal cancer cells M Sen, X Wang, FH Hamdan, J Rapp, J Eggert, RL Kosinsky, F Wegwitz, ... Clinical epigenetics 11, 1-16, 2019 | 59 | 2019 |
| USP22 exerts tumor-suppressive functions in colorectal cancer by decreasing mTOR activity RL Kosinsky, M Zerche, D Saul, X Wang, L Wohn, F Wegwitz, ... Cell Death & Differentiation 27 (4), 1328-1340, 2020 | 54 | 2020 |
| RNF40 regulates gene expression in an epigenetic context-dependent manner W Xie, S Nagarajan, SJ Baumgart, RL Kosinsky, Z Najafova, V Kari, ... Genome biology 18, 1-22, 2017 | 47 | 2017 |
| The histone methyltransferase DOT1L is required for proper DNA damage response, DNA repair, and modulates chemotherapy responsiveness V Kari, SK Raul, JM Henck, J Kitz, F Kramer, RL Kosinsky, N Übelmesser, ... Clinical epigenetics 11, 1-13, 2019 | 45 | 2019 |
| Modulation of fracture healing by the transient accumulation of senescent cells D Saul, DG Monroe, JL Rowsey, RL Kosinsky, SJ Vos, ML Doolittle, ... Elife 10, e69958, 2021 | 44 | 2021 |
| Effect of the lipoxygenase-inhibitors baicalein and zileuton on the vertebra in ovariectomized rats D Saul, S Gleitz, HH Nguyen, RL Kosinsky, S Sehmisch, DB Hoffmann, ... Bone 101, 134-144, 2017 | 35 | 2017 |
| USP22-dependent HSP90AB1 expression promotes resistance to HSP90 inhibition in mammary and colorectal cancer RL Kosinsky, M Helms, M Zerche, L Wohn, A Dyas, E Prokakis, ... Cell death & disease 10 (12), 911, 2019 | 34 | 2019 |
| Loss of RNF40 decreases NF-κB activity in colorectal cancer cells and reduces colitis burden in mice RL Kosinsky, RL Chua, M Qui, D Saul, D Mehlich, P Ströbel, ... Journal of Crohn's and Colitis 13 (3), 362-373, 2019 | 34 | 2019 |
| Usp22 deficiency impairs intestinal epithelial lineage specification in vivo RL Kosinsky, F Wegwitz, N Hellbach, M Dobbelstein, A Mansouri, T Vogel, ... Oncotarget 6 (35), 37906, 2015 | 33 | 2015 |
| The E3 ubiquitin ligase RNF40 suppresses apoptosis in colorectal cancer cells D Schneider, RL Chua, N Molitor, FH Hamdan, EM Rettenmeier, ... Clinical Epigenetics 11, 1-13, 2019 | 27 | 2019 |
| USP22 promotes HER2-driven mammary carcinoma aggressiveness by suppressing the unfolded protein response E Prokakis, A Dyas, R Grün, S Fritzsche, U Bedi, ZB Kazerouni, ... Oncogene 40 (23), 4004-4018, 2021 | 24 | 2021 |
| Single-cell transcriptomics reveals the expression of aging-and senescence-associated genes in distinct cancer cell populations D Saul, RL Kosinsky Cells 10 (11), 3126, 2021 | 22 | 2021 |
| Effect of the lipoxygenase inhibitor baicalein on muscles in ovariectomized rats D Saul, JH Kling, RL Kosinsky, DB Hoffmann, M Komrakova, M Wicke, ... Journal of Nutrition and Metabolism 2016 (1), 3703216, 2016 | 22 | 2016 |
| RNF20 and RNF40 regulate vitamin D receptor-dependent signaling in inflammatory bowel disease RL Kosinsky, M Zerche, AP Kutschat, A Nair, Z Ye, D Saul, M von Heesen, ... Cell Death & Differentiation 28 (11), 3161-3175, 2021 | 18 | 2021 |
| RNF40 exerts stage-dependent functions in differentiating osteoblasts and is essential for bone cell crosstalk Z Najafova, P Liu, F Wegwitz, M Ahmad, L Tamon, RL Kosinsky, W Xie, ... Cell Death & Differentiation 28 (2), 700-714, 2021 | 18 | 2021 |
| Effect of the lipoxygenase inhibitor baicalein on bone tissue and bone healing in ovariectomized rats D Saul, M Weber, MH Zimmermann, RL Kosinsky, DB Hoffmann, ... Nutrition & metabolism 16, 1-15, 2019 | 18 | 2019 |
| BMI1 maintains the Treg epigenomic landscape to prevent inflammatory bowel disease MM Gonzalez, AO Bamidele, PA Svingen, MR Sagstetter, TC Smyrk, ... The Journal of clinical investigation 131 (12), 2021 | 16 | 2021 |
