High-resolution structure and dynamics of mitochondrial complex I—Insights into the proton pumping mechanism K Parey, J Lasham, DJ Mills, A Djurabekova, O Haapanen, EG Yoga, ... Science advances 7 (46), eabj3221, 2021 | 84 | 2021 |
Oversized ubiquinones as molecular probes for structural dynamics of the ubiquinone reaction site in mitochondrial respiratory complex I S Uno, T Masuya, K Shinzawa-Itoh, J Lasham, O Haapanen, T Shiba, ... Journal of Biological Chemistry 295 (8), 2449-2463, 2020 | 26 | 2020 |
Tunnel dynamics of quinone derivatives and its coupling to protein conformational rearrangements in respiratory complex I J Lasham, O Haapanen, V Zickermann, V Sharma Biochimica et Biophysica Acta (BBA)-Bioenergetics 1864 (2), 148951, 2023 | 7 | 2023 |
Horizontal proton transfer across the antiporter-like subunits in mitochondrial respiratory complex I O Zdorevskyi, A Djurabekova, J Lasham, V Sharma Chemical Science 14 (23), 6309-6318, 2023 | 7 | 2023 |
Diverse reaction behaviors of artificial ubiquinones in mitochondrial respiratory complex I S Uno, T Masuya, O Zdorevskyi, R Ikunishi, K Shinzawa-Itoh, J Lasham, ... Journal of Biological Chemistry 298 (7), 2022 | 7 | 2022 |
Long-range electron proton coupling in respiratory complex I—insights from molecular simulations of the quinone chamber and antiporter-like subunits A Djurabekova, J Lasham, O Zdorevskyi, V Zickermann, V Sharma Biochemical Journal 481 (7), 499-514, 2024 | 6 | 2024 |
Role of protonation states in the stability of molecular dynamics simulations of high-resolution membrane protein structures J Lasham, A Djurabekova, V Zickermann, J Vonck, V Sharma The Journal of Physical Chemistry B 128 (10), 2304-2316, 2024 | 6 | 2024 |
Hydrogen bonding rearrangement by a mitochondrial disease mutation in cytochrome bc1 perturbs heme bH redox potential and spin state P Kuleta, J Lasham, M Sarewicz, I Ekiert, V Sharma, R Ekiert, A Osyczka Proceedings of the National Academy of Sciences 118 (33), e2026169118, 2021 | 4 | 2021 |
Nanobody engineering for SARS-CoV-2 neutralization and detection L Hannula, S Kuivanen, J Lasham, R Kant, L Kareinen, M Bogacheva, ... Microbiology spectrum 12 (4), e04199-22, 2024 | 3 | 2024 |
Targeting respiratory complex I—molecular mechanism and drug design V Sharma, J Lasham, O Haapanen Clinical Bioenergetics, 327-340, 2021 | 1 | 2021 |
Assessment of amino acid charge states based on cryo-electron microscopy and molecular dynamics simulations of respiratory complex I J Lasham, A Djurabekova, G Kolypetris, V Zickermann, J Vonck, ... Biochimica et Biophysica Acta (BBA)-Bioenergetics, 149512, 2024 | | 2024 |
Predictive Insights into Protonation States of Key Residues in Bioenergetic Proteins Using Conventional and Constant-pH MD Simulations J Lasham, V Sharma Biochimica et Biophysica Acta (BBA)-Bioenergetics 1865, 149327, 2024 | | 2024 |
The function and dysfunction of respiratory complexes studied by computational methods J Lasham Helsingin yliopisto, 2023 | | 2023 |