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Jonathan Lasham
Jonathan Lasham
在 helsinki.fi 的电子邮件经过验证
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High-resolution structure and dynamics of mitochondrial complex I—Insights into the proton pumping mechanism
K Parey, J Lasham, DJ Mills, A Djurabekova, O Haapanen, EG Yoga, ...
Science advances 7 (46), eabj3221, 2021
842021
Oversized ubiquinones as molecular probes for structural dynamics of the ubiquinone reaction site in mitochondrial respiratory complex I
S Uno, T Masuya, K Shinzawa-Itoh, J Lasham, O Haapanen, T Shiba, ...
Journal of Biological Chemistry 295 (8), 2449-2463, 2020
262020
Tunnel dynamics of quinone derivatives and its coupling to protein conformational rearrangements in respiratory complex I
J Lasham, O Haapanen, V Zickermann, V Sharma
Biochimica et Biophysica Acta (BBA)-Bioenergetics 1864 (2), 148951, 2023
72023
Horizontal proton transfer across the antiporter-like subunits in mitochondrial respiratory complex I
O Zdorevskyi, A Djurabekova, J Lasham, V Sharma
Chemical Science 14 (23), 6309-6318, 2023
72023
Diverse reaction behaviors of artificial ubiquinones in mitochondrial respiratory complex I
S Uno, T Masuya, O Zdorevskyi, R Ikunishi, K Shinzawa-Itoh, J Lasham, ...
Journal of Biological Chemistry 298 (7), 2022
72022
Long-range electron proton coupling in respiratory complex I—insights from molecular simulations of the quinone chamber and antiporter-like subunits
A Djurabekova, J Lasham, O Zdorevskyi, V Zickermann, V Sharma
Biochemical Journal 481 (7), 499-514, 2024
62024
Role of protonation states in the stability of molecular dynamics simulations of high-resolution membrane protein structures
J Lasham, A Djurabekova, V Zickermann, J Vonck, V Sharma
The Journal of Physical Chemistry B 128 (10), 2304-2316, 2024
62024
Hydrogen bonding rearrangement by a mitochondrial disease mutation in cytochrome bc1 perturbs heme bH redox potential and spin state
P Kuleta, J Lasham, M Sarewicz, I Ekiert, V Sharma, R Ekiert, A Osyczka
Proceedings of the National Academy of Sciences 118 (33), e2026169118, 2021
42021
Nanobody engineering for SARS-CoV-2 neutralization and detection
L Hannula, S Kuivanen, J Lasham, R Kant, L Kareinen, M Bogacheva, ...
Microbiology spectrum 12 (4), e04199-22, 2024
32024
Targeting respiratory complex I—molecular mechanism and drug design
V Sharma, J Lasham, O Haapanen
Clinical Bioenergetics, 327-340, 2021
12021
Assessment of amino acid charge states based on cryo-electron microscopy and molecular dynamics simulations of respiratory complex I
J Lasham, A Djurabekova, G Kolypetris, V Zickermann, J Vonck, ...
Biochimica et Biophysica Acta (BBA)-Bioenergetics, 149512, 2024
2024
Predictive Insights into Protonation States of Key Residues in Bioenergetic Proteins Using Conventional and Constant-pH MD Simulations
J Lasham, V Sharma
Biochimica et Biophysica Acta (BBA)-Bioenergetics 1865, 149327, 2024
2024
The function and dysfunction of respiratory complexes studied by computational methods
J Lasham
Helsingin yliopisto, 2023
2023
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