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Identification of Akt-independent regulation of hepatic lipogenesis by mammalian target of rapamycin (mTOR) complex 2 M Yuan, E Pino, L Wu, M Kacergis, AA Soukas Journal of Biological Chemistry 287 (35), 29579-29588, 2012 | 184 | 2012 |
Mitochondrial permeability uncouples elevated autophagy and lifespan extension B Zhou, J Kreuzer, C Kumsta, L Wu, KJ Kamer, L Cedillo, Y Zhang, S Li, ... Cell 177 (2), 299-314. e16, 2019 | 158 | 2019 |
Granzyme M directly cleaves inhibitor of caspase-activated DNase (CAD) to unleash CAD leading to DNA fragmentation H Lu, Q Hou, T Zhao, H Zhang, Q Zhang, L Wu, Z Fan The Journal of Immunology 177 (2), 1171-1178, 2006 | 97 | 2006 |
Cleavage of survivin by Granzyme M triggers degradation of the survivin-X-linked inhibitor of apoptosis protein (XIAP) complex to free caspase activity leading to cytolysis of … D Hu, S Liu, L Shi, C Li, L Wu, Z Fan Journal of Biological Chemistry 285 (24), 18326-18335, 2010 | 55 | 2010 |
Identification of SERPINB1 as a physiological inhibitor of human granzyme H L Wang, Q Li, L Wu, S Liu, Y Zhang, X Yang, P Zhu, H Zhang, K Zhang, ... The Journal of Immunology 190 (3), 1319-1330, 2013 | 50 | 2013 |
Metformin chlorination byproducts in drinking water exhibit marked toxicities of a potential health concern R Zhang, Y He, L Yao, J Chen, S Zhu, X Rao, P Tang, J You, G Hua, ... Environment International 146, 106244, 2021 | 43 | 2021 |
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Genome-wide RNAi screen for fat regulatory genes in C. elegans identifies a proteostasis-AMPK axis critical for starvation survival CM Webster, EC Pino, CE Carr, L Wu, B Zhou, L Cedillo, MC Kacergis, ... Cell reports 20 (3), 627-640, 2017 | 37 | 2017 |
Structural basis for proteolytic specificity of the human apoptosis-inducing granzyme M L Wu, L Wang, G Hua, K Liu, X Yang, Y Zhai, M Bartlam, F Sun, Z Fan The Journal of Immunology 183 (1), 421-429, 2009 | 30 | 2009 |
Granzyme F induces a novel death pathway characterized by Bid-independent cytochrome c release without caspase activation L Shi, L Wu, S Wang, Z Fan Cell Death & Differentiation 16 (12), 1694-1706, 2009 | 29 | 2009 |
A non-canonical role for the C. elegans dosage compensation complex in growth and metabolic regulation downstream of TOR complex 2 CM Webster, L Wu, D Douglas, AA Soukas Development 140 (17), 3601-3612, 2013 | 28 | 2013 |
Structural insights into the substrate specificity of human granzyme H: the functional roles of a novel RKR motif L Wang, K Zhang, L Wu, S Liu, H Zhang, Q Zhou, L Tong, F Sun, Z Fan The Journal of Immunology 188 (2), 765-773, 2012 | 27 | 2012 |
Low-density-lipoprotein-receptor-related protein 1 mediates Notch pathway activation W Bian, M Tang, H Jiang, W Xu, W Hao, Y Sui, Y Hou, L Nie, H Zhang, ... Developmental cell 56 (20), 2902-2919. e8, 2021 | 25 | 2021 |
Early-life vitamin B12 orchestrates lipid peroxidation to ensure reproductive success via SBP-1/SREBP1 in Caenorhabditis elegans S Qin, Y Wang, L Li, J Liu, C Xiao, D Duan, W Hao, C Qin, J Chen, L Yao, ... Cell Reports 40 (12), 2022 | 22 | 2022 |
Serum-and glucocorticoid-induced kinase drives hepatic insulin resistance by directly inhibiting AMP-activated protein kinase B Zhou, Y Zhang, S Li, L Wu, G Fejes-Toth, A Naray-Fejes-Toth, ... Cell reports 37 (1), 2021 | 16 | 2021 |
The antidiabetic drug metformin aids bacteria in hijacking vitamin B12 from the environment through RcdA L Yao, Y Wang, S Qin, S Zhu, L Wu Communications Biology 6 (1), 96, 2023 | 6 | 2023 |
Maternal aging increases offspring adult body size via transmission of donut-shaped mitochondria R Zhang, J Fang, T Qi, S Zhu, L Yao, G Fang, Y Li, X Zang, W Xu, W Hao, ... Cell Research 33 (11), 821-834, 2023 | 5 | 2023 |
Quantitative assessment of near-infrared fluorescent proteins H Zhang, S Papadaki, X Sun, X Wang, M Drobizhev, L Yao, M Rehbock, ... Nature Methods 20 (10), 1605-1616, 2023 | 5 | 2023 |