| Dnmt3a is essential for hematopoietic stem cell differentiation GA Challen, D Sun, M Jeong, M Luo, J Jelinek, JS Berg, C Bock, ... Nature genetics 44 (1), 23-31, 2012 | 1260 | 2012 |
| A side order of stem cells: the SP phenotype GA Challen, MH Little Stem cells 24 (1), 3-12, 2006 | 678 | 2006 |
| Distinct hematopoietic stem cell subtypes are differentially regulated by TGF-β1 GA Challen, NC Boles, SM Chambers, MA Goodell Cell stem cell 6 (3), 265-278, 2010 | 675 | 2010 |
| Clonal haematopoiesis harbouring AML-associated mutations is ubiquitous in healthy adults AL Young, GA Challen, BM Birmann, TE Druley Nature communications 7 (1), 12484, 2016 | 654 | 2016 |
| Mouse hematopoietic stem cell identification and analysis GA Challen, N Boles, KYK Lin, MA Goodell Cytometry Part A: The Journal of the International Society for Advancement …, 2009 | 461 | 2009 |
| Dnmt3a and Dnmt3b have overlapping and distinct functions in hematopoietic stem cells GA Challen, D Sun, A Mayle, M Jeong, M Luo, B Rodriguez, C Mallaney, ... Cell stem cell 15 (3), 350-364, 2014 | 369 | 2014 |
| Reprogrammable CRISPR/Cas9-based system for inducing site-specific DNA methylation JI McDonald, H Celik, LE Rois, G Fishberger, T Fowler, R Rees, A Kramer, ... Biology open 5 (6), 866-874, 2016 | 326 | 2016 |
| Large conserved domains of low DNA methylation maintained by Dnmt3a M Jeong, D Sun, M Luo, Y Huang, GA Challen, B Rodriguez, X Zhang, ... Nature genetics 46 (1), 17-23, 2014 | 319 | 2014 |
| Dnmt3a loss predisposes murine hematopoietic stem cells to malignant transformation A Mayle, L Yang, B Rodriguez, T Zhou, E Chang, CV Curry, GA Challen, ... Blood, The Journal of the American Society of Hematology 125 (4), 629-638, 2015 | 276 | 2015 |
| Chronic infection drives Dnmt3a-loss-of-function clonal hematopoiesis via IFNγ signaling D Hormaechea-Agulla, KA Matatall, DT Le, B Kain, X Long, P Kus, ... Cell stem cell 28 (8), 1428-1442. e6, 2021 | 206 | 2021 |
| Loss of Dnmt3a immortalizes hematopoietic stem cells in vivo M Jeong, HJ Park, H Celik, EL Ostrander, JM Reyes, A Guzman, ... Cell reports 23 (1), 1-10, 2018 | 201 | 2018 |
| Breast and pancreatic cancer interrupt IRF8-dependent dendritic cell development to overcome immune surveillance MA Meyer, JM Baer, BL Knolhoff, TM Nywening, RZ Panni, X Su, ... Nature communications 9 (1), 1250, 2018 | 196 | 2018 |
| Kidney side population reveals multilineage potential and renal functional capacity but also cellular heterogeneity GA Challen, I Bertoncello, JA Deane, SD Ricardo, MH Little Journal of the American Society of Nephrology 17 (7), 1896-1912, 2006 | 179 | 2006 |
| DNMT3A loss drives enhancer hypomethylation in FLT3-ITD-associated leukemias L Yang, B Rodriguez, A Mayle, HJ Park, X Lin, M Luo, M Jeong, CV Curry, ... Cancer cell 29 (6), 922-934, 2016 | 160 | 2016 |
| Identifying the molecular phenotype of renal progenitor cells GA Challen, G Martinez, MJ Davis, DF Taylor, M Crowe, RD Teasdale, ... Journal of the American Society of Nephrology 15 (9), 2344-2357, 2004 | 154 | 2004 |
| Type II interferon promotes differentiation of myeloid-biased hematopoietic stem cells KA Matatall, CC Shen, GA Challen, KY King Stem Cells 32 (11), 3023-3030, 2014 | 131 | 2014 |
| Runx1 isoforms show differential expression patterns during hematopoietic development but have similar functional effects in adult hematopoietic stem cells GA Challen, MA Goodell Experimental hematology 38 (5), 403-416, 2010 | 120 | 2010 |
| Clonal hematopoiesis: mechanisms driving dominance of stem cell clones GA Challen, MA Goodell Blood, The Journal of the American Society of Hematology 136 (14), 1590-1598, 2020 | 116 | 2020 |
| Inflammatory cytokines promote clonal hematopoiesis with specific mutations in ulcerative colitis patients CRC Zhang, D Nix, M Gregory, MA Ciorba, EL Ostrander, RD Newberry, ... Experimental hematology 80, 36-41. e3, 2019 | 109 | 2019 |
| Enforced differentiation of Dnmt3a-null bone marrow leads to failure with c-Kit mutations driving leukemic transformation H Celik, C Mallaney, A Kothari, EL Ostrander, E Eultgen, A Martens, ... Blood, The Journal of the American Society of Hematology 125 (4), 619-628, 2015 | 103 | 2015 |
