| Design, synthesis, and biological evaluation of potent and selective class IIa histone deacetylase (HDAC) inhibitors as a potential therapy for Huntington’s disease RW Bürli, CA Luckhurst, O Aziz, KL Matthews, D Yates, KA Lyons, ... Journal of medicinal chemistry 56 (24), 9934-9954, 2013 | 179 | 2013 |
| A ruthenium-catalyzed hydrative cyclization and [4+ 2] cycloaddition of yne-enones BM Trost, RE Brown, FD Toste Journal of the American Chemical Society 122 (24), 5877-5878, 2000 | 80 | 2000 |
| Potent, selective, and CNS-penetrant tetrasubstituted cyclopropane class IIa histone deacetylase (HDAC) inhibitors CA Luckhurst, P Breccia, AJ Stott, O Aziz, HL Birch, RW Bürli, ... ACS Medicinal Chemistry Letters 7 (1), 34-39, 2016 | 55 | 2016 |
| Evaluation of 5-(Trifluoromethyl)-1, 2, 4-oxadiazole-based class IIa HDAC inhibitors for Huntington’s disease AJ Stott, MC Maillard, V Beaumont, D Allcock, O Aziz, AH Borchers, ... ACS Medicinal Chemistry Letters 12 (3), 380-388, 2021 | 34 | 2021 |
| Bicyclic pyrimidin-4 (3h)-ones and analogues and derivatives thereof which modulate the function of the vanilloid-1-receptor (vr1) T Bayliss, G Hollingworth, R Jarvis, B Jones, T Sparey US Patent App. 10/578,855, 2007 | 32 | 2007 |
| 2, 3-Substituted Fused Pyrimidin-4 (3H)-Ones as VR1 Antagonists T Bayliss, RE Brown, GJ Hollingworth, BA Jones, CR Moyes, L Rogers US Patent App. 11/886,812, 2011 | 31 | 2011 |
| Studies towards the synthesis of lophotoxin and pukalide: Synthesis of the 14-membered macrocyclic core and some acyclic structural analogues I Paterson, RE Brown, CJ Urch Tetrahedron letters 40 (31), 5807-5810, 1999 | 29 | 1999 |
| Compounds activating VCP D1 ATPase enhance both autophagic and proteasomal neurotoxic protein clearance L Wrobel, SM Hill, A Djajadikerta, M Fernandez-Estevez, C Karabiyik, ... Nature Communications 13 (1), 4146, 2022 | 24 | 2022 |
| Developing HDAC4-selective protein degraders to investigate the role of HDAC4 in Huntington’s disease pathology N Macabuag, W Esmieu, P Breccia, R Jarvis, W Blackaby, O Lazari, ... Journal of Medicinal Chemistry 65 (18), 12445-12459, 2022 | 23 | 2022 |
| 2, 3 Substituted fused bicyclic pyrimidin-4 (3H)-ones modulating the function of the vanilliod-1receptor (VR1) RE Brown US Patent App. 11/919,960, 2009 | 23 | 2009 |
| 2, 3-Substituted fused bicyclic pyrimidin-4 (3H)-ones which modulating the function of the vanilloid-1 receptor (VR1) T Bayliss, RE Brown, GJ Hollingworth, AB Jones US Patent App. 11/920,065, 2009 | 23 | 2009 |
| Direct activation of KCC2 arrests benzodiazepine refractory status epilepticus and limits the subsequent neuronal injury in mice R Jarvis, SFJ Ng, AJ Nathanson, RA Cardarelli, K Abiraman, F Wade, ... Cell Reports Medicine 4 (3), 2023 | 22 | 2023 |
| Optimization of potent and selective ataxia telangiectasia-mutated inhibitors suitable for a proof-of-concept study in Huntington’s disease models L Toledo-Sherman, P Breccia, R Cachope, JR Bate, I Angulo-Herrera, ... Journal of Medicinal Chemistry 62 (6), 2988-3008, 2019 | 19 | 2019 |
| Novel compounds useful for the treatment of degenerative & inflamatory diseases PJ Edward, MS Chambers, CJM Menet, SR Fletcher, RE Jarvis, ... US Patent App. 11/983,402, 2009 | 17 | 2009 |
| Heteroaromatic urea derivatives as VR-1 receptor modulators for treating pain RE Brown, VA Doughty, GJ Hollingworth, AB Jones, MJ Lindon, ... US Patent 7,285,563, 2007 | 16 | 2007 |
| Structure-based exploration of selectivity for ATM inhibitors in Huntington’s disease A Van de Poël, L Toledo-Sherman, P Breccia, R Cachope, JR Bate, ... Journal of Medicinal Chemistry 64 (8), 5018-5036, 2021 | 12 | 2021 |
| Substituted amino heterocycles as VR-1 antagonists for treating pain R Brown, F Burkamp, V Doughty, S Fischer, G Hollingworth, A Jones, ... US Patent App. 10/545,877, 2006 | 9 | 2006 |
| Histone deacetylase inhibitors and compositions and methods of use thereof C Dominguez, I Muñoz-Sanjuán, M Maillard, HD Vater, RE Jarvis, ... US Patent App. 14/776,058, 2016 | 8 | 2016 |
| E-fluoro-4-(pyridin-2-yl)-piperidine-1-carboxamide derivatives and related compounds which modulate the function of the vanilloid-1 receptor (vr1) for the treatment of pain T Bayliss, R Brown, F Burkamp, B Jones, J Neduvelil US Patent App. 10/577,585, 2007 | 8 | 2007 |
| Histone deacetylase inhibitors and compositions and methods of use thereof C Dominguez, I Muñoz-Sanjuán, M Maillard, G Raphy, AF Haughan, ... US Patent 9,783,488, 2017 | 6 | 2017 |
