| Targeting RNA polymerase I with an oral small molecule CX-5461 inhibits ribosomal RNA synthesis and solid tumor growth D Drygin, A Lin, J Bliesath, CB Ho, SE O'Brien, C Proffitt, M Omori, ... Cancer research 71 (4), 1418-1430, 2011 | 636 | 2011 |
| Inhibition of RNA polymerase I as a therapeutic strategy to promote cancer-specific activation of p53 MJ Bywater, G Poortinga, E Sanij, N Hein, A Peck, C Cullinane, M Wall, ... Cancer cell 22 (1), 51-65, 2012 | 583 | 2012 |
| Dysregulation of the basal RNA polymerase transcription apparatus in cancer MJ Bywater, RB Pearson, GA McArthur, RD Hannan Nature Reviews Cancer 13 (5), 299-314, 2013 | 248 | 2013 |
| AKT promotes rRNA synthesis and cooperates with c-MYC to stimulate ribosome biogenesis in cancer JC Chan, KM Hannan, K Riddell, PY Ng, A Peck, RS Lee, S Hung, ... Science signaling 4 (188), ra56-ra56, 2011 | 172 | 2011 |
| RNA interference against human papillomavirus oncogenes in cervical cancer cells results in increased sensitivity to cisplatin LN Putral, MJ Bywater, W Gu, NA Saunders, BG Gabrielli, GR Leggatt, ... Molecular pharmacology 68 (5), 1311-1319, 2005 | 164 | 2005 |
| Combination therapy targeting ribosome biogenesis and mRNA translation synergistically extends survival in MYC-driven lymphoma JR Devlin, KM Hannan, N Hein, C Cullinane, E Kusnadi, PY Ng, ... Cancer discovery 6 (1), 59-70, 2016 | 128 | 2016 |
| Jak2V617F and Dnmt3a loss cooperate to induce myelofibrosis through activated enhancer-driven inflammation S Jacquelin, J Straube, L Cooper, T Vu, A Song, M Bywater, E Baxter, ... Blood, The Journal of the American Society of Hematology 132 (26), 2707-2721, 2018 | 71 | 2018 |
| The mTORC1 Inhibitor Everolimus Prevents and Treats Eμ-Myc Lymphoma by Restoring Oncogene-Induced Senescence M Wall, G Poortinga, KL Stanley, RK Lindemann, M Bots, CJ Chan, ... Cancer discovery 3 (1), 82-95, 2013 | 69 | 2013 |
| MPN: The molecular drivers of disease initiation, progression and transformation and their effect on treatment J Grabek, J Straube, M Bywater, SW Lane Cells 9 (8), 1901, 2020 | 47 | 2020 |
| Genomic characterisation of Eμ-Myc mouse lymphomas identifies Bcor as a Myc co-operative tumour-suppressor gene M Lefebure, RW Tothill, E Kruse, ED Hawkins, J Shortt, GM Matthews, ... Nature communications 8 (1), 1-10, 2017 | 47 | 2017 |
| Distinct effects of ruxolitinib and interferon-alpha on murine JAK2V617F myeloproliferative neoplasm hematopoietic stem cell populations RJ Austin, J Straube, C Bruedigam, G Pali, S Jacquelin, T Vu, J Green, ... Leukemia 34 (4), 1075-1089, 2020 | 44 | 2020 |
| Reactivation of Myc transcription in the mouse heart unlocks its proliferative capacity MJ Bywater, DL Burkhart, J Straube, A Sabò, V Pendino, JE Hudson, ... Nature communications 11 (1), 1827, 2020 | 43 | 2020 |
| Changes in long-range rDNA-genomic interactions associate with altered RNA polymerase II gene programs during malignant transformation J Diesch, MJ Bywater, E Sanij, DP Cameron, W Schierding, N Brajanovski, ... Communications Biology 2 (1), 39, 2019 | 40 | 2019 |
| Ubiquitous expression of the Pik3caH1047R mutation promotes hypoglycemia, hypoinsulinemia, and organomegaly KM Kinross, KG Montgomery, SP Mangiafico, LM Hare, M Kleinschmidt, ... The FASEB Journal 29 (4), 1426-1434, 2015 | 31 | 2015 |
| AKT signalling is required for ribosomal RNA synthesis and progression of Eμ‐Myc B‐cell lymphoma in vivo JR Devlin, KM Hannan, PY Ng, MJ Bywater, J Shortt, C Cullinane, ... The FEBS journal 280 (21), 5307-5316, 2013 | 22 | 2013 |
| Targeting cell cycle and apoptosis to overcome chemotherapy resistance in acute myeloid leukemia VY Ling, J Straube, W Godfrey, R Haldar, Y Janardhanan, L Cooper, ... Leukemia 37 (1), 143-153, 2023 | 20 | 2023 |
| Hematopoietic stem and progenitor cell-restricted Cdx2 expression induces transformation to myelodysplasia and acute leukemia T Vu, J Straube, AH Porter, M Bywater, A Song, V Ling, L Cooper, G Pali, ... Nature communications 11 (1), 3021, 2020 | 19 | 2020 |
| Oncogenic drivers dictate immune control of acute myeloid leukemia RJ Austin, J Straube, R Halder, Y Janardhanan, C Bruedigam, ... Nature Communications 14 (1), 2155, 2023 | 9 | 2023 |
| Determination of the physiological and pathological roles of E2F3 in adult tissues I Gamper, DL Burkhart, MJ Bywater, D Garcia, CH Wilson, PA Kreuzaler, ... Scientific Reports 7 (1), 9932, 2017 | 9 | 2017 |
| Paving the way to improve therapy for Myeloproliferative Neoplasms M Bywater, SW Lane Nature Communications 13 (1), 5025, 2022 | 4 | 2022 |
