| Cloning of a new cytokine that induces IFN-γ production by T cells H Okamura, H Tsutsui, T Komatsu, M Yutsudo, A Hakura, T Tanimoto, ... Nature 378 (6552), 88-91, 1995 | 3758 | 1995 |
| Targeted disruption of the MyD88 gene results in loss of IL-1-and IL-18-mediated function O Adachi, T Kawai, K Takeda, M Matsumoto, H Tsutsui, M Sakagami, ... Immunity 9 (1), 143-150, 1998 | 2588 | 1998 |
| Interleukin-18 regulates both Th1 and Th2 responses K Nakanishi, T Yoshimoto, H Tsutsui, H Okamura Annual review of immunology 19 (1), 423-474, 2001 | 1733 | 2001 |
| Activation of interferon-γ inducing factor mediated by interleukin-1β converting enzyme Y Gu, K Kuida, H Tsutsui, G Ku, K Hsiao, MA Fleming, N Hayashi, ... Science 275 (5297), 206-209, 1997 | 1527 | 1997 |
| Defective NK cell activity and Th1 response in IL-18–deficient mice K Takeda, H Tsutsui, T Yoshimoto, O Adachi, N Yoshida, T Kishimoto, ... Immunity 8 (3), 383-390, 1998 | 1154 | 1998 |
| Interleukin-18 is a unique cytokine that stimulates both Th1 and Th2 responses depending on its cytokine milieu K Nakanishi, T Yoshimoto, H Tsutsui, H Okamura Cytokine & growth factor reviews 12 (1), 53-72, 2001 | 974 | 2001 |
| Hepatocyte growth factor gene therapy of liver cirrhosis in rats T Ueki, Y Kaneda, H Tsutsui, K Nakanishi, Y Sawa, R Morishita, ... Nature medicine 5 (2), 226-230, 1999 | 825 | 1999 |
| SOCS-1 participates in negative regulation of LPS responses R Nakagawa, T Naka, H Tsutsui, M Fujimoto, A Kimura, T Abe, E Seki, ... Immunity 17 (5), 677-687, 2002 | 806 | 2002 |
| Regulation of interferon-γ production by IL-12 and IL-18 H Okamura, S Kashiwamura, H Tsutsui, T Yoshimoto, K Nakanishi Current opinion in immunology 10 (3), 259-264, 1998 | 671 | 1998 |
| Interleukin-18: a novel cytokine that augments both innate and acquired immunity H Okamura, H Tsutsui, SI Kashiwamura, T Yoshimoto, K Nakanishi Advances in immunology 70, 281-312, 1998 | 598 | 1998 |
| IFN-gamma-inducing factor up-regulates Fas ligand-mediated cytotoxic activity of murine natural killer cell clones. H Tsutsui, K Nakanishi, K Matsui, K Higashino, H Okamura, Y Miyazawa, ... Journal of immunology (Baltimore, Md.: 1950) 157 (9), 3967-3973, 1996 | 586 | 1996 |
| IL-18, although antiallergic when administered with IL-12, stimulates IL-4 and histamine release by basophils T Yoshimoto, H Tsutsui, K Tominaga, K Hoshino, H Okamura, S Akira, ... Proceedings of the National Academy of Sciences 96 (24), 13962-13966, 1999 | 563 | 1999 |
| Expression and function of TNF-related apoptosis-inducing ligand on murine activated NK cells N Kayagaki, N Yamaguchi, M Nakayama, K Takeda, H Akiba, H Tsutsui, ... The Journal of Immunology 163 (4), 1906-1913, 1999 | 462 | 1999 |
| IL-18 induction of IgE: dependence on CD4+ T cells, IL-4 and STAT6 T Yoshimoto, H Mizutani, H Tsutsui, N Noben-Trauth, K Yamanaka, ... Nature immunology 1 (2), 132-137, 2000 | 445 | 2000 |
| IL-18 accounts for both TNF-alpha-and Fas ligand-mediated hepatotoxic pathways in endotoxin-induced liver injury in mice. H Tsutsui, K Matsui, N Kawada, Y Hyodo, N Hayashi, H Okamura, ... Journal of immunology (Baltimore, Md.: 1950) 159 (8), 3961-3967, 1997 | 432 | 1997 |
| Pathophysiological roles of interleukin-18 in inflammatory liver diseases. H Tsutsui, K Matsui, H Okamura, K Nakanishi Immunological reviews 174 (1), 2000 | 385 | 2000 |
| Contribution of IL-33–activated type II innate lymphoid cells to pulmonary eosinophilia in intestinal nematode-infected mice K Yasuda, T Muto, T Kawagoe, M Matsumoto, Y Sasaki, K Matsushita, ... Proceedings of the National Academy of Sciences 109 (9), 3451-3456, 2012 | 366 | 2012 |
| Caspase-1-independent, Fas/Fas ligand–mediated IL-18 secretion from macrophages causes acute liver injury in mice H Tsutsui, N Kayagaki, K Kuida, H Nakano, N Hayashi, K Takeda, ... Immunity 11 (3), 359-367, 1999 | 343 | 1999 |
| Critical roles of myeloid differentiation factor 88-dependent proinflammatory cytokine release in early phase clearance of Listeria monocytogenes in mice E Seki, H Tsutsui, NM Tsuji, N Hayashi, K Adachi, H Nakano, ... The Journal of Immunology 169 (7), 3863-3868, 2002 | 335 | 2002 |
| Cutting edge: generation of IL-18 receptor-deficient mice: evidence for IL-1 receptor-related protein as an essential IL-18 binding receptor K Hoshino, H Tsutsui, T Kawai, K Takeda, K Nakanishi, Y Takeda, S Akira The Journal of Immunology 162 (9), 5041-5044, 1999 | 334 | 1999 |
