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brian LOCKHART
brian LOCKHART
Head of Companion Diagnostics
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标题
引用次数
引用次数
年份
The MCL1 inhibitor S63845 is tolerable and effective in diverse cancer models
A Kotschy, Z Szlavik, J Murray, J Davidson, AL Maragno, ...
Nature 538 (7626), 477-482, 2016
10462016
Amnesia induced in mice by centrally administered β-amyloid peptides involves cholinergic dysfunction
T Maurice, BP Lockhart, A Privat
Brain research 706 (2), 181-193, 1996
6671996
Neuroprotective and anti-amnesic potentials of sigma (σ) receptor ligands
T Maurice, BP Lockhart
Progress in Neuro-Psychopharmacology and Biological Psychiatry 21 (1), 69-102, 1997
2891997
A convenient extension of the Wessely–Moser rearrangement for the synthesis of substituted alkylaminoflavones as neuroprotective agents in vitro
R Larget, B Lockhart, P Renard, M Largeron
Bioorganic & medicinal chemistry letters 10 (8), 835-838, 2000
1502000
Inhibitors of free radical formation fail to attenuate direct β‐amyloid25–35 peptide‐mediated neurotoxicity in rat hippocampal cultures
BP Lockhart, C Benicourt, JL Junien, A Privat
Journal of neuroscience research 39 (4), 494-505, 1994
1391994
Only a subset of Met-activated pathways are required to sustain oncogene addiction
A Bertotti, MF Burbridge, S Gastaldi, F Galimi, D Torti, E Medico, ...
Science signaling 2 (100), ra80-ra80, 2009
1032009
Genetic deletion of trace amine 1 receptors reveals their role in auto-inhibiting the actions of ecstasy (MDMA)
B Di Cara, R Maggio, G Aloisi, JM Rivet, EG Lundius, T Yoshitake, ...
Journal of Neuroscience 31 (47), 16928-16940, 2011
1012011
Neuropilin-1 is upregulated in hepatocellular carcinoma and contributes to tumour growth and vascular remodelling
M Bergé, D Allanic, P Bonnin, C de Montrion, J Richard, M Suc, JF Boivin, ...
Journal of hepatology 55 (4), 866-875, 2011
992011
S49076 is a novel kinase inhibitor of MET, AXL, and FGFR with strong preclinical activity alone and in association with bevacizumab
MF Burbridge, CJ Bossard, C Saunier, I Fejes, A Bruno, S Léonce, G Ferry, ...
Molecular cancer therapeutics 12 (9), 1749-1762, 2013
952013
New quinolinic derivatives as centrally active antioxidants
G Dorey, B Lockhart, P Lestage, P Casara
Bioorganic & Medicinal Chemistry Letters 10 (9), 935-939, 2000
952000
Synthesis and in vitro evaluation of new 8-amino-1, 4-benzoxazine derivatives as neuroprotective antioxidants
M Largeron, B Lockhart, B Pfeiffer, MB Fleury
Journal of medicinal chemistry 42 (24), 5043-5052, 1999
911999
Distinct neuroprotective profiles for σ ligands against N-methyl-d-aspartate (NMDA), and hypoxia-mediated neurotoxicity in neuronal culture toxicity studies
BP Lockhart, P Soulard, C Benicourt, A Privat, JL Junien
Brain research 675 (1-2), 110-120, 1995
841995
Nox4 mediates the expression of plasminogen activator inhibitor-1 via p38 MAPK pathway in cultured human endothelial cells
A Jaulmes, P Sansilvestri-Morel, G Rolland-Valognes, F Bernhardt, ...
Thrombosis research 124 (4), 439-446, 2009
712009
Cognition enhancing or neuroprotective compounds for the treatment of cognitive disorders: why? when? which?
BP Lockhart, PJ Lestage
Experimental gerontology 38 (1-2), 119-128, 2003
692003
Inhibition of rabies virus transcription in rat cortical neurons with the dissociative anesthetic ketamine
BP Lockhart, N Tordo, H Tsiang
Antimicrobial agents and chemotherapy 36 (8), 1750-1755, 1992
691992
Reversion of β25–35-amyloid peptide-induced amnesia by NMDA receptor-associated glycine site agonists
T Maurice, BP Lockhart, TP Su, A Privat
Brain research 731 (1-2), 249-253, 1996
681996
Neuroprotective effects of modulators of P2 receptors in primary culture of CNS neurones
C Volonte, MT Ciotti, N D’Ambrosi, B Lockhart, M Spedding
Neuropharmacology 38 (9), 1335-1342, 1999
651999
Synthesis, structure, and neuroprotective properties of novel imidazolyl nitrones
A Dhainaut, A Tizot, E Raimbaud, B Lockhart, P Lestage, S Goldstein
Journal of medicinal chemistry 43 (11), 2165-2175, 2000
622000
Novel 2-alkylamino-1, 4-benzoxazine derivatives as potent neuroprotective agents: structure− activity relationship studies
E Blattes, B Lockhart, P Lestage, L Schwendimann, P Gressens, ...
Journal of medicinal chemistry 48 (4), 1282-1286, 2005
602005
Exploring Functional β-Cell Heterogeneity In Vivo Using PSA-NCAM as a Specific Marker
M Karaca, J Castel, C Tourrel-Cuzin, M Brun, A Géant, M Dubois, ...
PLoS One 4 (5), e5555, 2009
562009
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