Design and application of diabodies, triabodies and tetrabodies for cancer targeting A Todorovska, RC Roovers, O Dolezal, AA Kortt, HR Hoogenboom, ... Journal of immunological methods 248 (1-2), 47-66, 2001 | 439 | 2001 |
Dimeric and trimeric antibodies: high avidity scFvs for cancer targeting AA Kortt, O Dolezal, BE Power, PJ Hudson Biomolecular engineering 18 (3), 95-108, 2001 | 298 | 2001 |
Inhibitors of histone acetyltransferases KAT6A/B induce senescence and arrest tumour growth JB Baell, DJ Leaver, SJ Hermans, GL Kelly, MS Brennan, NL Downer, ... Nature 560 (7717), 253-257, 2018 | 215 | 2018 |
Structure of an IgNAR-AMA1 complex: targeting a conserved hydrophobic cleft broadens malarial strain recognition KA Henderson, VA Streltsov, AM Coley, O Dolezal, PJ Hudson, ... Structure 15 (11), 1452-1466, 2007 | 134 | 2007 |
HBO1 is required for the maintenance of leukaemia stem cells L MacPherson, J Anokye, MM Yeung, EYN Lam, YC Chan, CF Weng, ... Nature 577 (7789), 266-270, 2020 | 129 | 2020 |
A global benchmark study using affinity-based biosensors RL Rich, GA Papalia, PJ Flynn, J Furneisen, J Quinn, JS Klein, ... Analytical biochemistry 386 (2), 194-216, 2009 | 124 | 2009 |
ScFv multimers of the anti-neuraminidase antibody NC10: shortening of the linker in single-chain Fv fragment assembled in VL to VH orientation drives the formation of dimers … O Dolezal, LA Pearce, LJ Lawrence, AJ McCoy, PJ Hudson, AA Kortt Protein engineering 13 (8), 565-574, 2000 | 112 | 2000 |
Engineered antibody intervention strategies for Alzheimer's disease and related dementias by targeting amyloid and toxic oligomers R Robert, O Dolezal, L Waddington, MK Hattarki, R Cappai, CL Masters, ... Protein Engineering, Design & Selection 22 (3), 199-208, 2009 | 97 | 2009 |
Engineering of an anti‐epidermal growth factor receptor antibody to single chain format and labeling by sortase A‐mediated protein ligation MP Madej, G Coia, CC Williams, JM Caine, LA Pearce, R Attwood, ... Biotechnology and bioengineering 109 (6), 1461-1470, 2012 | 85 | 2012 |
Recombinant single-chain antibody peptide conjugates expressed in Escherichia coli for the rapid diagnosis of HIV GG Lilley, O Dolezal, CJ Hillyard, C Bernard, PJ Hudson Journal of Immunological Methods 171 (2), 211-226, 1994 | 83 | 1994 |
Parallel screening of low molecular weight fragment libraries: do differences in methodology affect hit identification? J Wielens, SJ Headey, DI Rhodes, RJ Mulder, O Dolezal, JJ Deadman, ... Journal of Biomolecular Screening 18 (2), 147-159, 2013 | 81 | 2013 |
Rapid optimization of a peptide inhibitor of malaria parasite invasion by comprehensive N-methyl scanning KS Harris, JL Casey, AM Coley, JA Karas, JK Sabo, YY Tan, O Dolezal, ... Journal of Biological Chemistry 284 (14), 9361-9371, 2009 | 79 | 2009 |
Discovery and biophysical characterization of 2-amino-oxadiazoles as novel antagonists of PqsR, an important regulator of Pseudomonas aeruginosa virulence M Zender, T Klein, C Henn, B Kirsch, CK Maurer, D Kail, C Ritter, ... Journal of medicinal chemistry 56 (17), 6761-6774, 2013 | 78 | 2013 |
Targeting the hepatitis B virus precore antigen with a novel IgNAR single variable domain intrabody R Walsh, S Nuttall, P Revill, D Colledge, L Cabuang, S Soppe, O Dolezal, ... Virology 411 (1), 132-141, 2011 | 75 | 2011 |
Shark Variable New Antigen Receptor (VNAR) Single Domain Antibody Fragments: Stability and Diagnostic Applications K Griffiths, O Dolezal, K Parisi, J Angerosa, C Dogovski, M Barraclough, ... Antibodies 2 (1), 66-81, 2013 | 72 | 2013 |
i-bodies, human single domain antibodies that antagonize chemokine receptor CXCR4 K Griffiths, O Dolezal, B Cao, SK Nilsson, HB See, KDG Pfleger, M Roche, ... Journal of Biological Chemistry 291 (24), 12641-12657, 2016 | 69 | 2016 |
Small molecule inhibitors of the LEDGF site of human immunodeficiency virus integrase identified by fragment screening and structure based design TS Peat, DI Rhodes, N Vandegraaff, G Le, JA Smith, LJ Clark, ED Jones, ... PloS one 7 (7), e40147, 2012 | 62 | 2012 |
Native state mass spectrometry, surface plasmon resonance, and X-ray crystallography correlate strongly as a fragment screening combination LA Woods, O Dolezal, B Ren, JH Ryan, TS Peat, SA Poulsen Journal of Medicinal Chemistry 59 (5), 2192-2204, 2016 | 55 | 2016 |
An efficient high-throughput screening method for MYST family acetyltransferases, a new class of epigenetic drug targets H Falk, T Connor, H Yang, KJ Loft, JL Alcindor, G Nikolakopoulos, ... Journal of biomolecular screening 16 (10), 1196-1205, 2011 | 54 | 2011 |
A Human Monoclonal Antibody against Insulin-Like Growth Factor-II Blocks the Growth of Human Hepatocellular Carcinoma Cell Lines In vitro and In vivo DT Dransfield, EH Cohen, Q Chang, LG Sparrow, JD Bentley, O Dolezal, ... Molecular cancer therapeutics 9 (6), 1809-1819, 2010 | 52 | 2010 |