Remdesivir and SARS-CoV-2: Structural requirements at both nsp12 RdRp and nsp14 Exonuclease active-sites A Shannon, NTT Le, B Selisko, C Eydoux, K Alvarez, JC Guillemot, ... Antiviral research 178, 104793, 2020 | 337 | 2020 |
Rapid incorporation of Favipiravir by the fast and permissive viral RNA polymerase complex results in SARS-CoV-2 lethal mutagenesis A Shannon, B Selisko, NTT Le, J Huchting, F Touret, G Piorkowski, ... Nature communications 11 (1), 4682, 2020 | 234 | 2020 |
Favipiravir strikes the SARS-CoV-2 at its Achilles heel, the RNA polymerase A Shannon, B Selisko, NTT Le, J Huchting, F Touret, G Piorkowski, ... BioRxiv, 2020 | 112 | 2020 |
A dual mechanism of action of AT-527 against SARS-CoV-2 polymerase A Shannon, V Fattorini, B Sama, B Selisko, M Feracci, C Falcou, P Gauffre, ... Nature Communications 13 (1), 621, 2022 | 67 | 2022 |
Inhibition of SARS-CoV-2 polymerase by nucleotide analogs from a single-molecule perspective M Seifert, SC Bera, P Van Nies, RN Kirchdoerfer, A Shannon, TTN Le, ... Elife 10, e70968, 2021 | 62 | 2021 |
Drugs against SARS‐CoV‐2: What do we know about their mode of action? C Valle, B Martin, F Touret, A Shannon, B Canard, JC Guillemot, ... Reviews in medical virology 30 (6), 1-10, 2020 | 43 | 2020 |
Simultaneous uncoupled expression and purification of the Dengue virus NS3 protease and NS2B co-factor domain AE Shannon, KJ Chappell, MJ Stoermer, SY Chow, WM Kok, DP Fairlie, ... Protein expression and purification 119, 124-129, 2016 | 29 | 2016 |
Efficient delivery of dengue virus subunit vaccines to the skin by microprojection arrays DA Muller, ACI Depelsenaire, AE Shannon, D Watterson, SR Corrie, ... Vaccines 7 (4), 189, 2019 | 28 | 2019 |
Evaluation of AT-752, a Double Prodrug of a Guanosine Nucleotide Analog with In Vitro and In Vivo Activity against Dengue and Other Flaviviruses SS Good, A Shannon, K Lin, A Moussa, JG Julander, P La Colla, G Collu, ... Antimicrobial agents and chemotherapy 65 (11), 10.1128/aac. 00988-21, 2021 | 26 | 2021 |
Kill or corrupt: Mechanisms of action and drug-resistance of nucleotide analogues against SARS-CoV-2 A Shannon, B Canard Antiviral Research 210, 105501, 2023 | 18 | 2023 |
A fluorescence-based high throughput-screening assay for the SARS-CoV RNA synthesis complex C Eydoux, V Fattorini, A Shannon, B Didier, B Canard, JC Guillemot Journal of Virological Methods 288, 114013, 2021 | 18 | 2021 |
Protein-primed RNA synthesis in SARS-CoVs and structural basis for inhibition by AT-527 A Shannon, V Fattorini, B Sama, B Selisko, M Feracci, C Falcou, P Gauffre, ... BioRxiv, 2021.03. 23.436564, 2021 | 16 | 2021 |
Signatures and mechanisms of efficacious therapeutic ribonucleotides against SARS-CoV-2 revealed by analysis of its replicase using magnetic tweezers M Seifert, SC Bera, P van Nies, RN Kirchdoerfer, A Shannon, X Meng, ... | 13 | 2020 |
Product release is rate-limiting for catalytic processing by the Dengue virus protease AE Shannon, MM Pedroso, KJ Chappell, D Watterson, S Liebscher, ... Scientific Reports 6 (1), 37539, 2016 | 11 | 2016 |
A N7-guanine RNA cap methyltransferase signature-sequence as a genetic marker of large genome, non-mammalian Tobaniviridae F Ferron, HJ Debat, A Shannon, E Decroly, B Canard NAR Genomics and Bioinformatics 2 (1), lqz022, 2020 | 8 | 2020 |
AT-752 targets multiple sites and activities on the Dengue virus replication enzyme NS5 M Feracci, C Eydoux, V Fattorini, LL Bello, P Gauffre, B Selisko, ... Antiviral research 212, 105574, 2023 | 6 | 2023 |
Structure and sequence requirements for RNA capping at the venezuelan equine encephalitis virus RNA 5′ end O Ortega Granda, C Valle, A Shannon, E Decroly, B Canard, B Coutard, ... Journal of virology 95 (15), 10.1128/jvi. 00777-21, 2021 | 5 | 2021 |
A second type of N7-guanine RNA cap methyltransferase in an unusual locus of a large RNA virus genome A Shannon, B Sama, P Gauffre, T Guez, F Debart, JJ Vasseur, E Decroly, ... Nucleic Acids Research 50 (19), 11186-11198, 2022 | 3 | 2022 |
An exonuclease-resistant chain-terminating nucleotide analogue targeting the SARS-CoV-2 replicase complex A Shannon, A Chazot, M Feracci, C Falcou, V Fattorini, B Selisko, S Good, ... Nucleic Acids Research 52 (3), 1325-1340, 2024 | 1 | 2024 |
Niran interfering drugs for sars-cov-2 mutant therapy JP Sommadossi, K Lin, A Moussa, B Canard, A Shannon US Patent App. 18/132,300, 2023 | 1 | 2023 |