| Genome-scale CRISPR-mediated control of gene repression and activation LA Gilbert, MA Horlbeck, B Adamson, JE Villalta, Y Chen, EH Whitehead, ... Cell 159 (3), 647-661, 2014 | 2800 | 2014 |
| The CoQ oxidoreductase FSP1 acts parallel to GPX4 to inhibit ferroptosis K Bersuker, JM Hendricks, Z Li, L Magtanong, B Ford, PH Tang, ... Nature 575 (7784), 688-692, 2019 | 2220 | 2019 |
| Distinct BH3 domains either sensitize or activate mitochondrial apoptosis, serving as prototype cancer therapeutics A Letai, MC Bassik, LD Walensky, MD Sorcinelli, S Weiler, SJ Korsmeyer Cancer cell 2 (3), 183-192, 2002 | 2122 | 2002 |
| JNK1-mediated phosphorylation of Bcl-2 regulates starvation-induced autophagy Y Wei, S Pattingre, S Sinha, M Bassik, B Levine Molecular cell 30 (6), 678-688, 2008 | 1532 | 2008 |
| Exercise-induced BCL2-regulated autophagy is required for muscle glucose homeostasis C He, MC Bassik, V Moresi, K Sun, Y Wei, Z Zou, Z An, J Loh, J Fisher, ... Nature 481 (7382), 511-515, 2012 | 1295 | 2012 |
| RETRACTED: Proapoptotic BAX and BAK Modulate the Unfolded Protein Response by a Direct Interaction with IRE1α C Hetz, P Bernasconi, J Fisher, AH Lee, MC Bassik, B Antonsson, ... Science 312 (5773), 572-576, 2006 | 818 | 2006 |
| CMTM6 maintains the expression of PD-L1 and regulates anti-tumour immunity ML Burr, CE Sparbier, YC Chan, JC Williamson, K Woods, PA Beavis, ... Nature 549 (7670), 101-105, 2017 | 766 | 2017 |
| Lipid-droplet-accumulating microglia represent a dysfunctional and proinflammatory state in the aging brain J Marschallinger, T Iram, M Zardeneta, SE Lee, B Lehallier, MS Haney, ... Nature neuroscience 23 (2), 194-208, 2020 | 725 | 2020 |
| Proapoptotic BAX and BAK regulate the type 1 inositol trisphosphate receptor and calcium leak from the endoplasmic reticulum SA Oakes, L Scorrano, JT Opferman, MC Bassik, M Nishino, T Pozzan, ... Proceedings of the National Academy of Sciences 102 (1), 105-110, 2005 | 533 | 2005 |
| Directed evolution using dCas9-targeted somatic hypermutation in mammalian cells GT Hess, L Frésard, K Han, CH Lee, A Li, KA Cimprich, SB Montgomery, ... Nature methods 13 (12), 1036-1042, 2016 | 508 | 2016 |
| Synergistic drug combinations for cancer identified in a CRISPR screen for pairwise genetic interactions K Han, EE Jeng, GT Hess, DW Morgens, A Li, MC Bassik Nature biotechnology 35 (5), 463-474, 2017 | 498 | 2017 |
| Discovery of common and rare genetic risk variants for colorectal cancer JR Huyghe, SA Bien, TA Harrison, HM Kang, S Chen, SL Schmit, ... Nature genetics 51 (1), 76-87, 2019 | 453 | 2019 |
| Systematic comparison of CRISPR/Cas9 and RNAi screens for essential genes DW Morgens, RM Deans, A Li, MC Bassik Nature biotechnology 34 (6), 634-636, 2016 | 441 | 2016 |
| A systematic mammalian genetic interaction map reveals pathways underlying ricin susceptibility MC Bassik, M Kampmann, RJ Lebbink, S Wang, MY Hein, I Poser, ... Cell 152 (4), 909-922, 2013 | 420 | 2013 |
| DNA vector chemistry: the covalent attachment of signal peptides to plasmid DNA MG Sebestyén, JJ Ludtke, MC Bassik, G Zhang, V Budker, EA Lukhtanov, ... Nature biotechnology 16 (1), 80-85, 1998 | 373 | 1998 |
| Phosphorylation of BCL‐2 regulates ER Ca2+ homeostasis and apoptosis MC Bassik, L Scorrano, SA Oakes, T Pozzan, SJ Korsmeyer The EMBO journal 23 (5), 1207-1216, 2004 | 361 | 2004 |
| Genome-scale measurement of off-target activity using Cas9 toxicity in high-throughput screens DW Morgens, M Wainberg, EA Boyle, O Ursu, CL Araya, CK Tsui, ... Nature communications 8 (1), 15178, 2017 | 347 | 2017 |
| CD22 blockade restores homeostatic microglial phagocytosis in ageing brains JV Pluvinage, MS Haney, BAH Smith, J Sun, T Iram, L Bonanno, L Li, ... Nature 568 (7751), 187-192, 2019 | 340 | 2019 |
| Selective silencing of euchromatic L1s revealed by genome-wide screens for L1 regulators N Liu, CH Lee, T Swigut, E Grow, B Gu, MC Bassik, J Wysocka Nature 553 (7687), 228-232, 2018 | 292 | 2018 |
| Static and dynamic DNA loops form AP-1-bound activation hubs during macrophage development DH Phanstiel, K Van Bortle, D Spacek, GT Hess, MS Shamim, I Machol, ... Molecular cell 67 (6), 1037-1048. e6, 2017 | 272 | 2017 |
