Tunable Cysteine-Targeting Electrophilic Heteroaromatic Warheads Induce Ferroptosis E Karaj, SH Sindi, N Kuganesan, L Perera, W Taylor, LMV Tillekeratne Journal of Medicinal Chemistry 65 (17), 11788–11817, 2022 | 30 | 2022 |
A new class of cytotoxic agents targets tubulin and disrupts microtubule dynamics AA Al-Hamashi, R Koranne, S Dlamini, A Alqahtani, E Karaj, MS Rashid, ... Bioorganic chemistry 116, 105297, 2021 | 18 | 2021 |
Photoaffinity Labeling and Bioorthogonal ligation: Two Critical Tools for Designing “Fish Hooks” to Scout for Target Proteins E Karaj, SH Sindi, LMV Tillekeratne Bioorganic & Medicinal Chemistry 62, 116721, 2022 | 13 | 2022 |
First-in-class dual mechanism ferroptosis-HDAC inhibitor hybrids E Karaj, SH Sindi, N Kuganesan, RA Koranne, JR Knoff, AW James, Y Fu, ... Journal of medicinal chemistry 65 (21), 14764-14791, 2022 | 11 | 2022 |
Pharmacophore optimization of imidazole chalcones to modulate microtubule dynamics E Karaj, S Dlamini, R Koranne, SH Sindi, L Perera, WR Taylor, ... Bioorganic Chemistry 122, 105700, 2022 | 8 | 2022 |
Rational design of metabolically stable HDAC inhibitors: An overhaul of trifluoromethyl ketones B Riddhidev, K Endri, L Sabitri, L N Kotsull, K Nishanth, I Dragan, ... European journal of medicinal chemistry 244, 114807, 2022 | 7 | 2022 |
The structural simplification of lysergic acid as a natural lead for synthesizing novel anti-Alzheimer agents M Alzweiri, AS Alsegiani, E Karaj, DA Almarghalani, Y Tabaza, ZA Shah, ... Bioorganic & medicinal chemistry letters 47, 128205, 2021 | 5 | 2021 |
Leveraging multi-mode microextraction and liquid chromatography stationary phases for quantitative analysis of neurotoxin β-N-methylamino-L-alanine and other non-proteinogenic … RV Emmons, E Karaj, E Cudjoe, DS Bell, LMV Tillekeratne, E Gionfriddo Journal of Chromatography A 1685, 463636, 2022 | 4 | 2022 |
Imidazole-based anticancer agents and derivatives thereof, and methods of making and using same V Tillekeratne, A Al-Hamashi, S Dlamini, ASS Alqahtani, E Karaj US Patent 11,098,038, 2021 | 2 | 2021 |
BIFUNCTIONAL CHIMERIC MOLECULES FOR LABELING OF KINASES WITH TARGET BINDING MOIETIES AND METHODS OF USE THEREOF A CHOUDHARY, S SINGHA, P SINGH, S CHAUDHARY, S Sameek, ... | | 2024 |
Metabolically Stable HDAC Inhibitors with Trifluoromethylpyruvamide as Metal-Binding Group E Karaj, LV Tillekeratne, R Banerjee, WR Taylor US Patent App. 18/585,551, 2024 | | 2024 |
CETZOLE Analogs as Potent Ferroptosis Inducers and Their Target Identification Using Covalent/Affinity Probes S Dlamini, S Mohajeri, N Kuganesan, SH Sindi, E Karaj, DS Rathnayake, ... Journal of Medicinal Chemistry 67 (18), 16107-16127, 2024 | | 2024 |
CHIMERIC SMALL MOLECULES FOR LABELING PROTEINS WITH IMMUNOGENIC MOIETIES AND METHODS OF USE THEREOF A CHOUDHARY, S SINGH, K PAL, E KARAJ, S SINDI, R PERGU, ... | | 2024 |
Ferroptosis-HDAC Inhibitor Hybrid Anticancer Agents V Tillekeratne, E Karaj, S Sindi, W Taylor US Patent App. 18/238,687, 2024 | | 2024 |
Medicinal & Chemical Biology Investigation of Ferroptosis Inducers & HDAC Inhibitors E Karaj The University of Toledo, 2022 | | 2022 |