| Broad-spectrum antiviral GS-5734 inhibits both epidemic and zoonotic coronaviruses TP Sheahan, AC Sims, RL Graham, VD Menachery, LE Gralinski, ... Science translational medicine 9 (396), eaal3653, 2017 | 1856 | 2017 |
| Therapeutic efficacy of the small molecule GS-5734 against Ebola virus in rhesus monkeys TK Warren, R Jordan, MK Lo, AS Ray, RL Mackman, V Soloveva, ... Nature 531 (7594), 381-385, 2016 | 1683 | 2016 |
| Coronavirus susceptibility to the antiviral remdesivir (GS-5734) is mediated by the viral polymerase and the proofreading exoribonuclease ML Agostini, EL Andres, AC Sims, RL Graham, TP Sheahan, X Lu, ... MBio 9 (2), 10.1128/mbio. 00221-18, 2018 | 1406 | 2018 |
| Discovery and Synthesis of a Phosphoramidate Prodrug of a Pyrrolo[2,1-f][triazin-4-amino] Adenine C-Nucleoside (GS-5734) for the Treatment of Ebola and … D Siegel, HC Hui, E Doerffler, MO Clarke, K Chun, L Zhang, S Neville, ... Journal of medicinal chemistry 60 (5), 1648-1661, 2017 | 763 | 2017 |
| GS-5734 and its parent nucleoside analog inhibit Filo-, Pneumo-, and Paramyxoviruses MK Lo, R Jordan, A Arvey, J Sudhamsu, P Shrivastava-Ranjan, AL Hotard, ... Scientific reports 7 (1), 43395, 2017 | 532 | 2017 |
| Nucleoside and nucleotide HIV reverse transcriptase inhibitors: 25 years after zidovudine T Cihlar, AS Ray Antiviral research 85 (1), 39-58, 2010 | 512 | 2010 |
| Toxicity of antiviral nucleoside analogs and the human mitochondrial DNA polymerase AA Johnson, AS Ray, J Hanes, Z Suo, JM Colacino, KS Anderson, ... Journal of Biological Chemistry 276 (44), 40847-40857, 2001 | 472 | 2001 |
| Mechanism of active renal tubular efflux of tenofovir AS Ray, T Cihlar, KL Robinson, L Tong, JE Vela, MD Fuller, LM Wieman, ... Antimicrobial agents and chemotherapy 50 (10), 3297-3304, 2006 | 421 | 2006 |
| Tenofovir alafenamide: a novel prodrug of tenofovir for the treatment of human immunodeficiency virus AS Ray, MW Fordyce, MJM Hitchcock Antiviral research 125, 63-70, 2016 | 401 | 2016 |
| Structural basis for RNA replication by the hepatitis C virus polymerase TC Appleby, JK Perry, E Murakami, O Barauskas, J Feng, A Cho, D Fox III, ... Science 347 (6223), 771-775, 2015 | 335 | 2015 |
| Intracellular metabolism and in vitro activity of tenofovir against hepatitis B virus WE Delaney IV, AS Ray, H Yang, X Qi, S Xiong, Y Zhu, MD Miller Antimicrobial agents and chemotherapy 50 (7), 2471-2477, 2006 | 322 | 2006 |
| GS-0976 reduces hepatic steatosis and fibrosis markers in patients with nonalcoholic fatty liver disease R Loomba, Z Kayali, M Noureddin, P Ruane, EJ Lawitz, M Bennett, ... Gastroenterology 155 (5), 1463-1473. e6, 2018 | 303 | 2018 |
| Inhibition of acetyl-CoA carboxylase by phosphorylation or the inhibitor ND-654 suppresses lipogenesis and hepatocellular carcinoma JSV Lally, S Ghoshal, DK DePeralta, O Moaven, L Wei, R Masia, ... Cell metabolism 29 (1), 174-182. e5, 2019 | 274 | 2019 |
| Contribution of the organic anion transporter OAT2 to the renal active tubular secretion of creatinine and mechanism for serum creatinine elevations caused by cobicistat EI Lepist, X Zhang, J Hao, J Huang, A Kosaka, G Birkus, BP Murray, ... Kidney international 86 (2), 350-357, 2014 | 266 | 2014 |
| Synthesis and antiviral activity of a series of 1′-substituted 4-aza-7, 9-dideazaadenosine C-nucleosides A Cho, OL Saunders, T Butler, L Zhang, J Xu, JE Vela, JY Feng, AS Ray, ... Bioorganic & medicinal chemistry letters 22 (8), 2705-2707, 2012 | 250 | 2012 |
| Acetyl‐C o A Carboxylase Inhibition Reverses NAFLD and Hepatic Insulin Resistance but Promotes Hypertriglyceridemia in Rodents L Goedeke, J Bates, DF Vatner, RJ Perry, T Wang, R Ramirez, L Li, ... Hepatology 68 (6), 2197-2211, 2018 | 216 | 2018 |
| Transporters in drug development: 2018 ITC recommendations for transporters of emerging clinical importance MJ Zamek‐Gliszczynski, ME Taub, PP Chothe, X Chu, KM Giacomini, ... Clinical Pharmacology & Therapeutics 104 (5), 890-899, 2018 | 214 | 2018 |
| Acetyl-CoA carboxylase inhibitor GS-0976 for 12 weeks reduces hepatic de novo lipogenesis and steatosis in patients with nonalcoholic steatohepatitis EJ Lawitz, A Coste, F Poordad, N Alkhouri, N Loo, BJ McColgan, ... Clinical Gastroenterology and Hepatology 16 (12), 1983-1991. e3, 2018 | 199 | 2018 |
| Implications of efficient hepatic delivery by tenofovir alafenamide (GS-7340) for hepatitis B virus therapy E Murakami, T Wang, Y Park, J Hao, EI Lepist, D Babusis, AS Ray Antimicrobial agents and chemotherapy 59 (6), 3563-3569, 2015 | 188 | 2015 |
| Role of purine nucleoside phosphorylase in interactions between 2′, 3′-dideoxyinosine and allopurinol, ganciclovir, or tenofovir AS Ray, L Olson, A Fridland Antimicrobial agents and chemotherapy 48 (4), 1089-1095, 2004 | 181 | 2004 |
Jay P. Parrish, PhD.Venture Partner, Arch Venture Partners在 archventure.com 的电子邮件经过验证
