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Michael A. Metrick II
Michael A. Metrick II
UCSF - Resident Pathologist-Scientist
在 ucsf.edu 的电子邮件经过验证 - 首页
标题
引用次数
引用次数
年份
4-Repeat tau seeds and templating subtypes as brain and CSF biomarkers of frontotemporal lobar degeneration
E Saijo, MA Metrick, S Koga, P Parchi, I Litvan, S Spina, A Boxer, ...
Acta neuropathologica 139, 63-77, 2020
1262020
Seeding selectivity and ultrasensitive detection of tau aggregate conformers of Alzheimer disease
A Kraus, E Saijo, MA Metrick, K Newell, CJ Sigurdson, G Zanusso, ...
Acta neuropathologica 137, 585-598, 2019
1162019
A single ultrasensitive assay for detection and discrimination of tau aggregates of Alzheimer and Pick diseases
MA Metrick, NC Ferreira, E Saijo, A Kraus, K Newell, G Zanusso, ...
Acta neuropathologica communications 8, 1-13, 2020
822020
Million-fold sensitivity enhancement in proteopathic seed amplification assays for biospecimens by Hofmeister ion comparisons
MA Metrick, N do Carmo Ferreira, E Saijo, AG Hughson, A Kraus, C Orrú, ...
Proceedings of the National Academy of Sciences 116 (46), 23029-23039, 2019
782019
Ultrasensitive RT-QuIC seed amplification assays for disease-associated tau, α-synuclein, and prion aggregates
E Saijo, BR Groveman, A Kraus, M Metrick, CD Orrù, AG Hughson, ...
Protein Misfolding Diseases: Methods and Protocols, 19-37, 2019
692019
The effects of buffers and pH on the thermal stability, unfolding and substrate binding of RecA
MA Metrick, JE Temple, G MacDonald
Biophysical chemistry 184, 29-36, 2013
472013
Detection of chronic wasting disease in mule and white-tailed deer by RT-QuIC analysis of outer ear
NC Ferreira, JM Charco, J Plagenz, CD Orru, ND Denkers, MA Metrick, ...
Scientific reports 11 (1), 7702, 2021
372021
Hofmeister ion effects on the solvation and thermal stability of model proteins lysozyme and myoglobin
MA Metrick II, G MacDonald
Colloids and Surfaces A: Physicochemical and Engineering Aspects 469, 242-251, 2015
372015
Hofmeister ion-induced changes in water structure correlate with changes in solvation of an aggregated protein complex
TP Light, KM Corbett, MA Metrick, G MacDonald
Langmuir 32 (5), 1360-1369, 2016
252016
Variable-field analytical ultracentrifugation: I. Time-optimized sedimentation equilibrium
J Ma, M Metrick, R Ghirlando, H Zhao, P Schuck
Biophysical journal 109 (4), 827-837, 2015
122015
Computational maturation of a single-domain antibody against Aβ42 aggregation
J Lin, C Figazzolo, MA Metrick, P Sormanni, M Vendruscolo
Chemical Science 12 (41), 13940-13948, 2021
72021
Secondary processes dominate the quiescent, spontaneous aggregation of α-synuclein at physiological pH with sodium salts
RI Horne, MA Metrick, W Man, DJ Rinauro, ZF Brotzakis, S Chia, G Meisl, ...
ACS Chemical Neuroscience 14 (17), 3125-3131, 2023
62023
Case report of a patient with unclassified tauopathy with molecular and neuropathological features of both progressive supranuclear palsy and corticobasal degeneration
S Koga, MA Metrick, LI Golbe, A Santambrogio, M Kim, AI Soto-Beasley, ...
Acta Neuropathologica Communications 11 (1), 88, 2023
32023
A brain‐seeded fibril amplification models the aggregation process of tau in Alzheimer’s disease for drug discovery
A Santambrogio, M Metrick, T Löhr, R Horne, M Vendruscolo
Alzheimer's & Dementia 19, e082750, 2023
12023
Secondary Processes Dominate the Quiescent, Spontaneous Aggregation of α‑Synuclein at Physiological pH with Sodium Salts
MA Metrick, W Man, DJ Rinauro, ZF Brotzakis, S Chia, RI Horne, G Meisl, ...
American Chemical Society, 2023
2023
Amyloid seeding assays for the selective amplification of tau aggregates from human brain homogenates
M Metrick
2022
The aggregation kinetics of α-Synuclein at neutral pH under quiescent conditions
WK Man, MA Metrick, DJ Rinauro, M Vendruscolo
Biophysical Journal 121 (3), 299a-300a, 2022
2022
Therapeutic drug targeting in Alzheimer's disease
R Geiser, M Sanguanini, R Staats, D Rinauro, M Metrick, P Ciryam, ...
Biophysical Journal 121 (3), 190a, 2022
2022
RT-QuIC as an antemortem diagnostic tool to detect chronic wasting disease in deer skin
NC Ferreira, JM Charco, MA Metrick, CD Orru, AG Hughson, J Castilla, ...
PRION 13, 139-140, 2019
2019
Hofmeister Ion and Cosolvent Effects on the Structure, Aggregation, and Backbone Solvation of RecA
TP Light, KM Corbett, MA Metrick, G MacDonald
Biophysical Journal 108 (2), 217a, 2015
2015
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